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    Glossary Epidermis Development

    process by which skin's outer layer forms and matures

    Epidermis development refers to the process by which the outermost layer of the skin, known as the epidermis, forms and matures. This involves the differentiation and proliferation of keratinocytes, the primary cell type in the epidermis, as well as the formation of specialized structures like hair follicles and sweat glands. Proper epidermis development is crucial for creating a protective barrier against environmental damage and pathogens.

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    1. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    2. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013 · 83 citations
    3. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    4. Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development International Journal of Molecular Sciences · 2016 · 14 citations
    5. Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development Frontiers in Cell and Developmental Biology · 2020 · 12 citations
    6. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    7. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis The EMBO Journal · 2013 · 65 citations
    8. Gene-knockout mice with abnormal epidermal and hair follicular development Journal of dermatological science · 1998 · 11 citations
    9. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    10. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Development · 1991 · 409 citations
    11. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    12. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    13. Transcriptomic landscape of early hair follicle and epidermal development Cell Reports · 2023 · 23 citations
    14. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    15. 1313 Fzd2 controls multiple aspects of epidermal development through distinct signaling mechanisms Journal of Investigative Dermatology · 2018 · 1 citations
    16. 890 Development of pigmented reconstructed human epidermis model containing human melanoblasts from keratinocyte culture Journal of Investigative Dermatology · 2019
    17. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    18. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    19. THE EXPRESSION CHARACTERISTICS AND THEIR BIOLOGICAL SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR IN RAT SKINS AT DIFFERENT DEVELOPMENT STAGES Chinese Journal of Reparative and Reconstructive Surgery · 2001
    20. 476 Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells Journal of Investigative Dermatology · 2017
    21. A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development 2002
    22. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    23. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    24. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    25. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    26. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    27. Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration Biomaterials · 2024 · 25 citations
    28. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa International journal of molecular sciences · 2020 · 15 citations
    29. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity PloS one · 2020 · 7 citations
    30. 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis 2018