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    Glossary Epidermal Keratins

    proteins that strengthen skin, hair, and nails

    Epidermal keratins are a type of protein found in the outer layer of the skin, known as the epidermis. They help provide structural strength and protection to the skin, hair, and nails. These proteins are essential for maintaining the integrity and resilience of the skin, making it resistant to physical stress and environmental damage.

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    1. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    2. Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins Journal of Cell Science · 2011 · 76 citations
    3. The Functional Diversity of Epidermal Keratins Revealed by the Partial Rescue of the Keratin 14 Null Phenotype by Keratin 16 1999 · 53 citations
    4. Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis 1987 · 81 citations
    5. Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals Molecular Biology and Evolution · 2018 · 68 citations
    6. Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour European Journal of Histochemistry · 2013 · 28 citations
    7. Severe Abnormalities in the Oral Mucosa Induced by Suprabasal Expression of Epidermal Keratin K10 in Transgenic Mice Journal of Biological Chemistry · 2002 · 15 citations
    8. Immunoperoxidase anti-keratin staining of epidermal and pilar cysts British Journal of Dermatology · 1984 · 10 citations
    9. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. The Journal of Cell Biology · 1982 · 277 citations
    10. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    11. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    12. The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus PLoS ONE · 2019 · 9 citations
    13. Molecular Genetics of Inherited Disorders of Epidermal Keratins Encyclopedia of Life Sciences · 2009
    14. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    15. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    16. Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10. PubMed · 1994 · 13 citations
    17. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    18. Epidermal cyst containing numerous spherules of keratin British Journal of Dermatology · 2004 · 36 citations
    19. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    20. Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter Molecular Therapy · 2007 · 52 citations
    21. The ‘melanocyte-keratin’ mystery revisited: neither normal human epidermal nor hair follicle melanocytes express keratin 16 or keratin 6<i>in situ</i> British Journal of Dermatology · 2009 · 8 citations
    22. 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation 2021
    23. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    24. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis Differentiation · 1999 · 75 citations
    25. Keratin metabolism in the epidermis and hair of mice with experimental diabetes Bulletin of Experimental Biology and Medicine · 1992 · 3 citations
    26. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    27. Cornification in reptilian epidermis occurs through the deposition of keratin‐associated beta‐proteins (beta‐keratins) onto a scaffold of intermediate filament keratins Journal of Morphology · 2012 · 33 citations
    28. Pre-keratin isolated from epidermal microsomes Biochimica et Biophysica Acta (BBA) - Protein Structure · 1970 · 7 citations
    29. Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells. PubMed · 2005 · 25 citations
    30. Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice The FASEB Journal · 2004 · 49 citations