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    Glossary Epidermal Development

    process of forming and maturing the skin's outer layer

    Epidermal development refers to the process by which the outermost layer of the skin, known as the epidermis, forms and matures. This involves the differentiation and proliferation of keratinocytes, the primary cell type in the epidermis, as well as the formation of specialized structures like hair follicles and sweat glands. This process is crucial for creating a protective barrier against environmental damage and pathogens.

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    1. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes & Development · 1991 · 409 citations
    2. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    3. p63 regulates <i>Satb1</i> to control tissue-specific chromatin remodeling during development of the epidermis The Journal of Cell Biology · 2011 · 166 citations
    4. Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells International Journal of Molecular Sciences · 2013 · 83 citations
    5. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis The EMBO Journal · 2013 · 65 citations
    6. Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis Proceedings of the National Academy of Sciences · 2017 · 59 citations
    7. Transcriptomic landscape of early hair follicle and epidermal development Cell Reports · 2023 · 23 citations
    8. Conditional Knockout in Mice Reveals the Critical Roles of Ppp2ca in Epidermis Development International Journal of Molecular Sciences · 2016 · 14 citations
    9. Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development Frontiers in Cell and Developmental Biology · 2020 · 12 citations
    10. Gene-knockout mice with abnormal epidermal and hair follicular development Journal of dermatological science · 1998 · 11 citations
    11. Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling PLOS ONE · 2012 · 9 citations
    12. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    13. 1313 Fzd2 controls multiple aspects of epidermal development through distinct signaling mechanisms Journal of Investigative Dermatology · 2018 · 1 citations
    14. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019
    15. THE EXPRESSION CHARACTERISTICS AND THEIR BIOLOGICAL SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR IN RAT SKINS AT DIFFERENT DEVELOPMENT STAGES Chinese Journal of Reparative and Reconstructive Surgery · 2001
    16. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    17. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    18. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    19. 476 Development of an intrinsic skin sensor for blood glucose level with CRISPR-mediated genome editing in epidermal stem cells Journal of Investigative Dermatology · 2017
    20. A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development 2002
    21. 890 Development of pigmented reconstructed human epidermis model containing human melanoblasts from keratinocyte culture Journal of Investigative Dermatology · 2019
    22. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    23. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    24. Development of pluripotent stem cell-derived epidermal organoids that generate effective extracellular vesicles in skin regeneration Biomaterials · 2024 · 25 citations
    25. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa International journal of molecular sciences · 2020 · 15 citations
    26. 1397 LSD1 is critical for epidermal development and skin barrier formation Journal of Investigative Dermatology · 2023
    27. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    28. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    29. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    30. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations