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    Glossary Epidermal Cell Proliferation

    process where skin cells divide and multiply for regeneration

    Epidermal Cell Proliferation, also known as Skin Cell Proliferation, refers to the process by which cells in the outermost layer of the skin (the epidermis) divide and multiply. This process is crucial for skin regeneration, wound healing, and maintaining the skin's barrier function. It involves the production of new cells to replace those that are shed or damaged, ensuring the skin remains healthy and functional.

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    1. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    2. Epidermal cell proliferation and modulation of the protective potency of dexamethasone against phorbol ester-induced ornithine decarboxylase activity Carcinogenesis · 1989 · 1 citations
    3. An estrogen receptor pathwayregulates thetelogen-anagen hair follicle transition andinfluences epidermal cell proliferation (epidermis/estrogen/keratinocyte/differentiation/mesenchymal 1996
    4. Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012 · 221 citations
    5. Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle Stem Cells · 2010 · 39 citations
    6. RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling PLoS ONE · 2017 · 21 citations
    7. Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis Development · 2003 · 421 citations
    8. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis Development · 2007 · 28 citations
    9. 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study Brazilian Journal of Medical and Biological Research · 2025 · 2 citations
    10. Type XVII collagen coordinates proliferation in the interfollicular epidermis eLife · 2017 · 124 citations
    11. Dermal-Epidermal Interactions--Follicle Derived Cell Populations in the Study of Hair-Growth Mechanisms. 1993 · 28 citations
    12. ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes 2021 · 4 citations
    13. The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model PLoS ONE · 2016 · 16 citations
    14. 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation Journal of Investigative Dermatology · 2024
    15. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging Aging Cell · 2020 · 23 citations
    16. Influence of an epidermal cell extract on skin healing and scar formation. PubMed · 1988 · 11 citations
    17. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    18. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    19. Urokinase is a Positive Regulator of Epidermal Proliferation In Vivo Journal of Investigative Dermatology · 1999 · 28 citations
    20. Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood Journal of Investigative Dermatology · 2007 · 18 citations
    21. Impaired Keratinocyte Proliferative and Clonogenic Potential in Transgenic Mice Overexpressing 14-3-3σ in the Epidermis Journal of Investigative Dermatology · 2011 · 15 citations
    22. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    23. Defining stem cell dynamics and migration during wound healing in mouse skin epidermis Nature Communications · 2017 · 363 citations
    24. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    25. High proliferation and delamination during skin epidermal stratification Nature Communications · 2021 · 51 citations
    26. Neuregulin3 alters cell fate in the epidermis and mammary gland BMC developmental biology · 2007 · 39 citations
    27. Wnt4 increases the thickness of the epidermis in burn wounds by activating canonical Wnt signalling and decreasing the cell junctions between epidermal cells Burns & Trauma · 2022 · 1 citations
    28. Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair Advances in Wound Care · 2019 · 10 citations
    29. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    30. 1349 Stimulation of hair follicle stem cell proliferation through an IL-1α dependent activation of γδT-cells 2018