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    Glossary Epidermal Development

    process of forming and maturing the skin's outer layer

    Epidermal development refers to the process by which the outermost layer of the skin, known as the epidermis, forms and matures. This involves the differentiation and proliferation of keratinocytes, the primary cell type in the epidermis, as well as the formation of specialized structures like hair follicles and sweat glands. This process is crucial for creating a protective barrier against environmental damage and pathogens.

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    1. Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development Developmental Cell · 2006 · 147 citations
    2. Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development Archives of Dermatological Research · 2013 · 19 citations
    3. Transcriptomic landscape of early hair follicle and epidermal development Cell Reports · 2023 · 23 citations
    4. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa International journal of molecular sciences · 2020 · 15 citations
    5. Transcriptomic landscape of early hair follicle and epidermal development bioRxiv (Cold Spring Harbor Laboratory) · 2022
    6. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris) Scientific reports · 2020 · 2 citations
    7. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (<i>Atelerix albiventris</i>) bioRxiv (Cold Spring Harbor Laboratory) · 2020
    8. Interplay between EDA-EDAR and WNT signalling pathways in the development of skin appendages in hypohidrotic ectodermal dysplasia Pediatria i Medycyna Rodzinna · 2025 · 1 citations
    9. Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development Mechanisms of Development · 1999 · 22 citations
    10. 706 Engrailed-1 promotes eccrine sweat gland development in permissive environments Journal of Investigative Dermatology · 2016
    11. Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program Signal Transduction and Targeted Therapy · 2026
    12. A transient dermal niche and dual epidermal programs underlie sweat gland development bioRxiv (Cold Spring Harbor Laboratory) · 2023
    13. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis 2023 · 1 citations
    14. Generalized Congenital Hypotrichosis in a Female Rottweiler Veterinary Dermatology · 1993 · 6 citations
    15. Sostdc1 defines the size and number of skin appendage placodes Developmental biology · 2012 · 56 citations
    16. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    17. Immunohistochemical Expression of the ${\alpha}$ - and ${\gamma}$ -catenin in the Fetal Skin Development Linchuang pifuke zazhi · 2004
    18. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012 · 85 citations
    19. Beauty is skin deep: the fascinating biology of the epidermis and its appendages. PubMed · 2000 · 65 citations
    20. Generalized pustular toxic erythema: pathogenetic relationship between pustule and epidermal appendage (hair follicle or sweat duct) Acta Dermato Venereologica · 1978 · 10 citations
    21. Cosmetics and hair and nails Elsevier eBooks · 1997
    22. Retinoic Acid and Mouse Skin Morphogenesis. II. Role of Epidermal Competence in Hair Glandular Metaplasia Developmental Biology · 1994 · 16 citations
    23. Scratching the surface of skin development Nature · 2007 · 788 citations
    24. Stabilization of epithelial β-catenin compromises mammary cell fate acquisition and branching morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    25. Expression of retinoic acid receptors and dermal-epidermal interactions during mouse skin morphogenesis 1992 · 3 citations
    26. A model system for long-term serum-free suspension organ culture of human fetal tissues: experiments on digits and skin from multiple body regions Cell and Tissue Research · 1997 · 17 citations
    27. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016 · 44 citations
    28. Immunolocalization of Scaffoldin, a Trichohyalin‐Like Protein, in the Epidermis of the Chicken Embryo The Anatomical Record · 2014 · 17 citations
    29. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    30. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations