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    Glossary Enzymatic Digestion

    Enzymatic digestion refers to the biochemical process in which enzymes break down complex molecules into simpler forms, facilitating nutrient absorption and metabolism. In the context of hair biology, enzymatic digestion can influence the degradation of hair follicle components and extracellular matrix proteins, which may play a role in hair loss conditions such as androgenetic alopecia. Key distinguishing characteristics include the specificity of enzymes for particular substrates and the role of this process in maintaining healthy hair follicle function and overall scalp health.

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    1. Impact of the Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells (AD-SVFs) and Human Adipose-Derived Mesenchymal Stem Cells (AD-MSCs): Enzymatic Digestion Versus Mechanical Centrifugation International Journal of Molecular Sciences · 2019 · 124 citations
    2. Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin International Journal of Molecular Sciences · 2025 · 1 citations
    3. 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation 2023
    4. Bioactive peptides derived from food proteins preventing lifestyle‐related diseases BioFactors · 2000 · 223 citations
    5. Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects International Journal of Molecular Sciences · 2021 · 70 citations
    6. Protocol for optimized dissociation of human scalp tissue for hair follicle transcriptomics by scRNA-seq STAR Protocols · 2024 · 2 citations
    7. Isolation and cultivation of the cells of hair follicles in vitro,and observation of the biological characteristics of them. Journal of Dermatology and Venereology · 2009 · 1 citations
    8. Ex vivo SIM-AFM measurements reveal the spatial correlation of stiffness and molecular distributions in 3D living tissue Acta Biomaterialia · 2024
    9. Human Hair Pigment: A Mild Isolation Procedure and a Method for Characterization 1981
    10. Comparative Study on Isolation and Culture Methods of Hair Follicle Stem Cells in Fine-wool Sheep China Animal Husbandry & Veterinary Medicine · 2013
    11. Inhibitory Effects of Edible and Medicinal Plant Extracts on the Enzymatic Activity of Pancreatic Lipase Journal of the Mexican chemical society · 2023
    12. Optimization of Bear Oil Extraction Process and Hair Growth Activity 2024
    13. Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia International journal of regenerative medicine · 2021
    14. The multipotency of adult vibrissa follicle stem cells Differentiation · 2009 · 8 citations
    15. In vitro identification of a stem cell population from canine hair follicle bulge region 2017 · 5 citations
    16. 1350 Human scalp skin as an abundant and accessible source for eccrine sweat gland isolation and organ culture 2018
    17. Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles 2024
    18. Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles Stem Cell Research & Therapy · 2024
    19. Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells Methods in molecular biology · 2017 · 8 citations
    20. Advantages of Incomplete Digestion in Human Hair Shaft Proteomics, a Focus on Cuticular Keratins Rapid Communications in Mass Spectrometry · 2025
    21. Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-pattern Baldness Journal of Investigative Dermatology · 1989 · 51 citations
    22. Pepsin Digestion for Proteomic Studies of the Human Hair Shaft Rapid Communications in Mass Spectrometry · 2025
    23. Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fibre Polymers · 2023
    24. Effect of ultrasound pre-treatment prior to enzymatic hydrolysis on physicochemical parameters of fish protein hydrolysates (FPH) extracted from side streams of Atlantic mackerel (Scomber scombrus) Frontiers in Sustainable Food Systems · 2024 · 6 citations
    25. Tamarillo Polyphenols Encapsulated-Cubosome: Formation, Characterization, Stability during Digestion and Application in Yoghurt Antioxidants · 2022 · 12 citations
    26. Effects of Tithonia diversifolia Extract as a Feed Additive on Digestibility and Performance of Hair Lambs Animals · 2024
    27. An Efficient Approach for β-Cyclodextrin Production from Raw Ginkgo Seed Powder Through High-Temperature Gelatinization and Enzymatic Conversion Catalysts · 2025
    28. An Electron Microscopy Study of Keratin Degradation by the Fungus Microsporum gypseum in vitro Mycoses · 2009 · 30 citations
    29. Solubility of Structurally Complicated Materials: 3. Hair 2009 · 30 citations
    30. Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry 2017 · 22 citations