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    Glossary Ectodysplasin A

    regulates development of skin, hair, teeth, and sweat glands

    Ectodysplasin A (Eda) is a protein crucial for the development of ectodermal tissues, which include skin, hair, teeth, and sweat glands. Mutations in the EDA gene can lead to ectodermal dysplasias, a group of disorders characterized by abnormalities in these tissues, often resulting in sparse hair, missing teeth, and reduced ability to sweat.

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    Research 30 of 318

    1. Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness Human Genetics · 2009 · 42 citations
    2. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    3. Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark Research Square (Research Square) · 2021 · 3 citations
    4. Stimulation of ectodermal organ development by Ectodysplasin-A1 Developmental Biology · 2003 · 249 citations
    5. p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss FEBS Letters · 2010 · 37 citations
    6. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations
    7. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    8. Molecular cloning,sequence analysis and expression of goat Edagene Journal of Northwest A & F University · 2012
    9. Feather arrays are patterned by interacting signalling and cell density waves PLoS Biology · 2019 · 133 citations
    10. A review of genetic researches of and rogenic alopecia Int J Genet · 2016
    11. The Roles of EDA2R in Ageing and Disease Aging Cell · 2025 · 1 citations
    12. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features Nature Communications · 2016 · 196 citations
    13. A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region is the Most Divergent Genomic Segment between Africans and East Asians in the Human Genome Human Biology · 2012 · 4 citations
    14. Significant Correction of Disease after Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007 · 109 citations
    15. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    16. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology · 2004 · 75 citations
    17. A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia: Figure 1 Journal of Medical Genetics · 2012 · 17 citations
    18. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    19. Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case–Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk Nutrients · 2025
    20. Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways Preprints.org · 2025
    21. Human Hair and the Impact of Cosmetic Procedures: A Review on Cleansing and Shape-Modulating Cosmetics Cosmetics · 2016 · 53 citations
    22. EDA Missense Variant in a Cat with X-Linked Hypohidrotic Ectodermal Dysplasia Genes · 2024
    23. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    24. Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia Orphanet Journal of Rare Diseases · 2021 · 2 citations
    25. Ancient Genomes Reveal the Evolutionary History and Origin of Cashmere-Producing Goats in China Molecular Biology and Evolution · 2020 · 27 citations
    26. Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats Scientific Reports · 2025 · 1 citations
    27. Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep Journal of Advanced Research · 2023 · 2 citations
    28. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015 · 128 citations
    29. Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss British Journal of Dermatology · 2012 · 38 citations
    30. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005 · 195 citations