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    Glossary Dermal Papilla Cells

    specialized cells at hair follicle base crucial for hair growth

    Dermal Papilla Cells (DPCs) are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by interacting with surrounding cells to regulate the hair growth cycle. These cells are essential for the formation of new hair follicles and are a key focus in research on hair loss treatments and regenerative medicine.

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    1. Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis Development · 2009 · 338 citations
    2. Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth Proceedings of the National Academy of Sciences of the United States of America · 2013 · 256 citations
    3. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    4. Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline Development · 2013 · 211 citations
    5. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    6. Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth ˜The œFASEB journal · 2002 · 190 citations
    7. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014 · 184 citations
    8. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995 · 173 citations
    9. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    10. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    11. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle Journal of Dermatological Science · 2004 · 149 citations
    12. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    13. Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp 1992 · 124 citations
    14. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice Scientific Reports · 2017 · 113 citations
    15. The in vitro properties of dermal papilla cell lines established from human hair follicles British Journal of Dermatology · 1986 · 106 citations
    16. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    17. Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015 · 93 citations
    18. Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin Physiological Genomics · 2004 · 90 citations
    19. Regulation of hair follicle development by exosomes derived from dermal papilla cells Biochemical and Biophysical Research Communications · 2018 · 87 citations
    20. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    21. Minoxidil-Induced Hair Growth is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001 · 83 citations
    22. Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus) PLoS ONE · 2013 · 81 citations
    23. Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration Biomaterials · 2008 · 80 citations
    24. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003 · 78 citations
    25. Sphere Formation Increases the Ability of Cultured Human Dermal Papilla Cells to Induce Hair Follicles from Mouse Epidermal Cells in a Reconstitution Assay Journal of Investigative Dermatology · 2011 · 75 citations
    26. Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019 · 71 citations
    27. Keratinocyte Growth Inhibition through the Modification of Wnt Signaling by Androgen in Balding Dermal Papilla Cells 2009 · 70 citations
    28. Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014 · 68 citations
    29. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011 · 68 citations
    30. Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells 2007 · 66 citations