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    Glossary Dermal Immune Cells

    specialized skin cells that defend against infections and damage

    Dermal immune cells are specialized cells located in the skin's dermis layer that play a crucial role in the body's immune response. They help protect against infections, heal wounds, and maintain skin health by identifying and responding to pathogens, damaged cells, and other harmful stimuli. These cells include various types such as macrophages, dendritic cells, and T cells, each with specific functions in immune surveillance and response.

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    1. Author response: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    2. Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration Genes & Diseases · 2025 · 1 citations
    3. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    4. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    5. Editor's evaluation: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    6. Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation induced tissue damage bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    7. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    8. Crosstalk between Immune Microenvironment and Hair Follicle Cells Underlies Sexual Dimorphism in Androgenetic Alopecia bioRxiv (Cold Spring Harbor Laboratory) · 2025
    9. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022 · 6 citations
    10. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta Immunity · 2018 · 96 citations
    11. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    12. Resident human dermal γδT-cells operate as stress-sentinels: Lessons from the hair follicle Journal of Autoimmunity · 2021 · 27 citations
    13. Human dermal Vδ1 + T-cells recognize “stressed” HFs and may induce alopecia areata Journal of Dermatological Science · 2017 · 1 citations
    14. Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells Frontiers in Cellular and Infection Microbiology · 2018 · 14 citations
    15. Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA) Research Square (Research Square) · 2021
    16. Human epidermal resident memory T cells: beyond the dermal perspective Frontiers in Immunology · 2026
    17. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    18. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019 · 306 citations
    19. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    20. Skinny Fat Cells Stimulate Wound Healing Cell stem cell · 2020 · 9 citations
    21. Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206+ Macrophage Accumulation in the Dermis JID Innovations · 2025
    22. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    23. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    24. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair Cell Stem Cell · 2020 · 124 citations
    25. Comparison of Calcium and Barium Microcapsules as Scaffolds in the Development of Artificial Dermal Papillae BioMed research international · 2016 · 3 citations
    26. The function of BST2 in γδ T Cells, CD8 T Cells, and macrophages in alopecia areata pathogenesis 4231 The Journal of Immunology · 2025
    27. Skin γδ T cell subsets have distinct functions in alopecia areata 3844 The Journal of Immunology · 2025
    28. Transient skin stretching stimulates immune surveillance and promotes vaccine delivery via hair follicles Cell Reports · 2025
    29. Exploration of Key Signals in Alopecia Areata by Cell-Cell Interaction Analysis International Journal of Pharma Medicine and Biological Sciences · 2025
    30. 1349 Stimulation of hair follicle stem cell proliferation through an IL-1α dependent activation of γδT-cells 2018