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    Glossary CYP11A1

    enzyme converting cholesterol to pregnenolone, initiating steroid hormone production

    CYP11A1, also known as Cytochrome P450 Family 11 Subfamily A Member 1 or P450scc, is an enzyme crucial for the production of steroid hormones. It catalyzes the conversion of cholesterol to pregnenolone, the first step in the biosynthesis of all steroid hormones, which are vital for various bodily functions including stress response, immune function, and regulation of inflammation.

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    Research 30 of 566

    1. The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China Clinical Cosmetic and Investigational Dermatology · 2021 · 10 citations
    2. Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia Acta dermato-venereologica · 2023 · 1 citations
    3. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    4. The significance of CYP11A1 expression in skin physiology and pathology Molecular and Cellular Endocrinology · 2021 · 91 citations
    5. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss British Journal of Dermatology · 2011 · 15 citations
    6. Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population Dermatology · 2015 · 7 citations
    7. Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model 2020 · 1 citations
    8. MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia Biochemical Pharmacology · 2026
    9. Coconut oil works as a gonadal feedback testosterone booster and increases pituitary aromatase (cyp19a1b) expression levels in fugu (Takifugu rubripes) Aquaculture · 2025
    10. Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss Egyptian Journal of Dermatology and Venerology · 2025
    11. Association of Cyp11a Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan Pakistan Journal of Health Sciences · 2025
    12. MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia European Journal of Pharmacology · 2024
    13. Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation Hormones · 2016
    14. The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population Postepy Dermatologii I Alergologii · 2021
    15. Cytochrome P450: A Target for Drug Development for Skin Diseases 2004 · 115 citations
    16. Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis BMC Medical Genomics · 2021 · 47 citations
    17. Studying the genetic predisposing factors in the pathogenesis of acne vulgaris Human Immunology · 2011 · 39 citations
    18. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology Genetics research international · 2018 · 29 citations
    19. Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment Scientific Reports · 2024 · 13 citations
    20. Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats? Human & Experimental Toxicology · 2016 · 13 citations
    21. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026
    22. Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome (PCOS) Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment Research Square (Research Square) · 2024
    23. 615 Evaluation of a combination of botanical extracts designed to protect hair and scalp from air pollutants: in vitro and clinical studies Journal of Investigative Dermatology · 2019
    24. Genetics and Epigenetics of Polycystic Ovary Syndrome IntechOpen eBooks · 2023
    25. Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 Nature Communications · 2019 · 115 citations
    26. Gene-wide association study between the aromatase gene (<i>CYP19A1</i>) and female pattern hair loss British Journal of Dermatology · 2009 · 77 citations
    27. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    28. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    29. In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond International Journal of Molecular Sciences · 2020 · 44 citations
    30. Aromatase deficiency in a male patient - Case report and review of the literature. Bone · 2016 · 36 citations