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    Did you mean Cyclooxygenase-2?
    Glossary Cyclooxygenase-2

    enzyme involved in inflammation and pain production

    Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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    Research 30 of 719

    1. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    2. Cyclooxygenases in the skin: pharmacological and toxicological implications Toxicology and applied pharmacology · 2003 · 165 citations
    3. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    4. Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L. Fitoterapia · 2010 · 61 citations
    5. Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation International Journal of Nanomedicine · 2020 · 45 citations
    6. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003 · 41 citations
    7. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    8. Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase Molecules · 2015 · 25 citations
    9. Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E<sub>2</sub>through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes Biomolecules & therapeutics · 2012 · 9 citations
    10. Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit during Hair Cycle Acta histochemica et cytochemica · 2008 · 9 citations
    11. 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts Journal of Investigative Dermatology · 2019
    12. Re: Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement The Journal of Urology · 2012
    13. 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice Journal of Investigative Dermatology · 2021
    14. New insights into the functions of Cox-2 in skin and esophageal malignancies Experimental & Molecular Medicine · 2020 · 54 citations
    15. Autotaxin–lysophosphatidic acid– LPA <sub>3</sub> signaling at the embryo‐epithelial boundary controls decidualization pathways The EMBO Journal · 2017 · 44 citations
    16. Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress International Journal of Nanomedicine · 2016 · 43 citations
    17. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    18. Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: Comparison with vitamin C effects International Journal of Trichology · 2020 · 8 citations
    19. UV light may induce hypertrichosis through production of PGE2 Medical hypotheses · 2006 · 7 citations
    20. A new target for squamous cell skin cancer? Experimental Dermatology · 2014 · 6 citations
    21. Cepharanthine: A review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19 2020 · 4 citations
    22. Molecular mechanisms underlying cashmere quality differences between Jiangnan cashmere goats and Changthangi pashmina goats Frontiers in Veterinary Science · 2025
    23. 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators Journal of Investigative Dermatology · 2017
    24. Functional Characterization of Callus Extracts of Apple 'Hirosaki' for Cosmetic Materials 2013
    25. Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin Cellular & Molecular Biology Letters · 2025
    26. Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism Annals of laboratory medicine · 2016
    27. Clinical Snippets Journal of Investigative Dermatology · 2003 · 1 citations
    28. Selective inhibition by minoxidil of prostacyclin production by cells in culture Biochemical Pharmacology · 1988 · 23 citations
    29. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors Journal of Ethnopharmacology · 2009 · 17 citations
    30. Enzymes British Journal of Pharmacology · 2008