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GlossaryCyclin D1

regulates cell cycle progression from G1 to S phase

Cyclin D1, also known as CCND1, is a protein that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where DNA replication occurs. It acts as a regulatory subunit for certain enzymes called cyclin-dependent kinases (CDKs), and its overexpression is often associated with various types of cancer, as it can lead to uncontrolled cell proliferation.

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Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

research Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

28 citations , July 2017 in “Expert Review of Anticancer Therapy”

Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.

research Cyclin D3 deficiency inhibits skin tumor development, but does not affect normal keratinocyte proliferation

2 citations , July 2017 in “Oncology Letters”

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

research Cyclin-Dependent Kinase 4/6 Inhibitors and Dermatologic Adverse Events: Results from the EADV Task Force “Dermatology for Cancer Patients” International Study

1 citations , July 2023 in “Cancers”

Skin side effects from CDK4/6 inhibitors in breast cancer patients are generally mild and treatable, allowing most patients to continue treatment.

research Cyclin‐dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle

1 citations , February 2022 in “Cell Biology International”

Changing CDK4 levels affects the number of stem cells in mouse hair follicles.

Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways

research Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100

29 citations , January 2021 in “Journal of nanobiotechnology”

Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.

research Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells

25 citations , March 2017 in “Steroids”

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations , January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57<scp>BL</scp>/6 mice

research Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice

21 citations , May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

research Effects of dihydrotestosterone on rat dermal papilla cells in vitro

19 citations , June 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

research Vanillic Acid Stimulates Anagen Signaling via the PI3K/Akt/ β-Catenin Pathway in Dermal Papilla Cells

14 citations , July 2020 in “Biomolecules & Therapeutics”

Vanillic acid from wheat bran may promote hair growth by activating certain cell pathways and reversing hormone-related hair loss.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.

research Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor

8 citations , March 2020 in “Frontiers in Cell and Developmental Biology”

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

research Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

7 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

Synthetic ceramides may help hair growth by boosting cell growth in hair follicles.

Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

5 citations , January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

research Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells

3 citations , December 2022 in “Nutrients”

Limonin from young citrus fruits may help with hair growth by affecting cell growth and hair cycle pathways.

research 698 Effect of lithocholic acid as a ligand of vitamin D receptor on hair growth in alopecia

May 2016 in “Journal of Investigative Dermatology”

Lithocholic acid helps hair growth and regeneration in alopecia by activating vitamin D receptors.

<i>In Vitro</i> and <i>In Vivo</i> Models for the Development of Hair Growth Materials By Regulating the <i>β</i>-Catenin Signaling Pathways

research In Vitro and In Vivo Models for the Development of Hair Growth Materials By Regulating the β-Catenin Signaling Pathways

February 2024 in “Journal of medicinal food”

The research found a way to develop hair growth materials by targeting a specific signaling pathway.

1272 p21Waf1/Cip1 is differentially expressed in epidermal versus follicular melanocytes and melanoma cells and is phenotypically regulated by UVB-mediated apoptosis

research 1272 p21Waf1/Cip1 is differentially expressed in epidermal versus follicular melanocytes and melanoma cells and is phenotypically regulated by UVB-mediated apoptosis

May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.

<scp><i>BUZZ</i></scp>: an essential gene for postinitiation root hair growth and a mediator of root architecture in <i>Brachypodium distachyon</i>

research BUZZ: an essential gene for postinitiation root hair growth and a mediator of root architecture in Brachypodium distachyon

July 2023 in “New phytologist”

The BUZZ gene is important for root hair growth and overall root structure in the plant Brachypodium distachyon.

Roles of <i>jumonji</i> and <i>jumonji</i> family genes in chromatin regulation and development

research Roles of jumonji and jumonji family genes in chromatin regulation and development

178 citations , May 2006 in “Developmental Dynamics”

Jumonji genes are important for development and their mutations can cause abnormalities, especially in the heart and brain.

research Author response: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

October 2022

Lhx2 is a crucial regulator of the Sonic Hedgehog signaling in early mouse retinal development.

research Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues

8 citations , January 2016 in “The Journal of Physiology”

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research The Effect of EGR1 on the Proliferation of Dermal Papilla Cells

5 citations , July 2022 in “Genes”

Increasing EGR1 levels makes hair root cells grow faster.

12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Role of the Wnt signaling pathway in keratoacanthoma

2 citations , November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

Heat‐treated <i>Limosilactobacillus fermentum</i><scp>LM1020</scp> with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double‐blind, randomized and placebo‐controlled clinical trial

research Heat‐treated Limosilactobacillus fermentumLM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double‐blind, randomized and placebo‐controlled clinical trial

May 2024 in “Journal of cosmetic dermatology”

Heat-treated Limosilactobacillus fermentum with menthol, salicylic acid, and panthenol promotes hair growth and balances scalp microbiome in people with androgenetic alopecia.

Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

research Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

April 2021 in “Current Topics in Nutraceutical Research”

Citron seed oil may help prevent or treat hair loss by promoting hair growth and increasing hair density.