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Isotretinoin can cause serious birth defects and needs careful use, especially in pregnant women.

A mutation in the EDNRA gene causes Oro-Oto-Cardiac syndrome, affecting face and heart development.

Achieving perfect facial plastic surgery requires personalized plans, proper patient selection, advanced techniques, and ongoing surgeon education.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

Treat adult facial vascular anomalies with lasers, surgery, or observation, depending on the patient's specific condition.

New techniques for treating scalp blood vessel malformations are effective and can have good cosmetic results.

Early diagnosis of Trichorhinophalangeal syndrome type 1 is crucial for treatment and was achieved through clinical examination and family history.

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

Treat pediatric skin issues with accurate diagnosis, multidisciplinary team, and various treatment options.

The supplement highlighted advancements and challenges in plastic and reconstructive surgery, including the impact of smoking, chemotherapy, and new treatments like Tafluprost for hair loss.

A 2-year-old boy with a rare brain malformation may have Gomez–López-Hernández syndrome.

The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.

Stem cells could improve plastic surgery but are not widely used due to cost and safety concerns.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

A specific mutation in the K25 gene causes a rare genetic disorder with curly hair at birth and later hair loss, along with dental issues.

Tattooing helps treat skin conditions, reconstruct nipple-areola, mark radiation fields, and locate lesions.

Certain cells in the adult mouse ear come from cranial neural crest cells, but muscle and hair cells do not.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

3D bioprinting in plastic surgery could lead to personalized grafts and fewer complications.

Patients with RASopathies have a higher risk of autoimmune disorders and should be routinely screened.

The document lists plastic surgery events and opportunities from 1997, including awards, workshops, and conferences.

The document concludes that changes in eyelashes and eyelid skin can indicate various local and systemic diseases.

Understanding scalp anatomy is crucial for successful and safe scalp surgery.

A new HRAS gene variant may cause a range of symptoms including intellectual disability and psychiatric issues.