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Isotretinoin can cause serious birth defects and needs careful use, especially in pregnant women.

Achieving perfect facial plastic surgery requires personalized plans, proper patient selection, advanced techniques, and ongoing surgeon education.

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

New techniques for treating scalp blood vessel malformations are effective and can have good cosmetic results.

Treat adult facial vascular anomalies with lasers, surgery, or observation, depending on the patient's specific condition.

Treat pediatric skin issues with accurate diagnosis, multidisciplinary team, and various treatment options.

A 2-year-old boy with a rare brain malformation may have Gomez–López-Hernández syndrome.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Early diagnosis of Trichorhinophalangeal syndrome type 1 is crucial for treatment and was achieved through clinical examination and family history.

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.

The supplement highlighted advancements and challenges in plastic and reconstructive surgery, including the impact of smoking, chemotherapy, and new treatments like Tafluprost for hair loss.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

Tattooing helps treat skin conditions, reconstruct nipple-areola, mark radiation fields, and locate lesions.

Certain cells in the adult mouse ear come from cranial neural crest cells, but muscle and hair cells do not.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Dermatoscopy is a useful tool for diagnosing hair disorders and can help choose samples for more detailed analysis.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.