232 citations
,
January 2002 in “Mechanisms of development” This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.
August 2019 in “Journal of Investigative Dermatology” This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.
16 citations
,
March 2021 in “EvoDevo” This study found that zebrafish and sticklebacks, despite differences in their tooth regeneration structures, share a similar genetic program during tooth regeneration, suggesting a conserved "successional dental epithelium" in vertebrates.
86 citations
,
April 2009 in “Journal of anatomy” This paper reviews the evolution of skin appendages and keratin-associated proteins among amniotes, proposing a model for their genetic divergence without new experimental results.
July 2025 in “Journal of Investigative Dermatology” Secreted inhibitors of Wnt and IGF signaling control hair and tooth development, creating species-specific patterns.
9 citations
,
October 1994 in “Brain Research” In this study, researchers observed that dorsal horn cells in fetal sheep begin responding to natural cutaneous stimulation by mid-gestation, coinciding with the initial innervation of the skin.
1 citations
,
November 2021 in “Revista Científica Hospital Santa Izabel” This study found that adhesion molecules, specifically integrins and cadherins, are crucial for the down growth and proliferation of hair follicles in human embryos and fetuses.
5 citations
,
June 2022 in “Scientific Reports” This study observed that basal cell carcinoma on the scalp shares more similar characteristics with truncal lesions than facial lesions, despite the scalp's proximity to the face.
156 citations
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January 1989 in “Genes & Development” This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.
16 citations
,
April 2021 in “Frontiers in Cell and Developmental Biology” This review discusses human hair follicle development and highlights the potential of creating human in vitro models and skin substitutes with hair follicles, reporting no new clinical results.
46 citations
,
August 2012 in “Experimental Dermatology” In this study, engineered skin substitutes containing murine dermal papilla cells developed hair follicle-like structures when grafted onto mice, suggesting a model for generating chimeric hair.
20 citations
,
February 1991 in “The Journal of Dermatologic Surgery and Oncology” This article discusses scalp reconstruction techniques using rotation flaps, with no new clinical results reported.
November 2009 in “Cambridge University Press eBooks” This article reviews the critical role of hairline design in hair restoration surgery and emphasizes the need for careful planning to avoid poor outcomes, without presenting new clinical data.
33 citations
,
October 2020 in “Frontiers in Cell and Developmental Biology” In this study, researchers found that during zebrafish telencephalon regeneration, the lesioned hemisphere showed distinct gene expression changes and activated Wnt/β-catenin signaling early after injury, suggesting this pathway's significant role in recovery.
19 citations
,
January 2015 in “Development” This study found that misexpression of Hoxc8 in mice led to ectopic mammary development and suggests Hox genes may play crucial roles in the regional specification and initiation of cutaneous accessory organs.
130 citations
,
February 2005 in “Proceedings of the National Academy of Sciences” This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.
July 2016 in “Indian journal of science and technology” In this study, researchers found that neonate hairs have a distinct microstructure with no medulla and smaller hair follicles compared to adult hairs.
56 citations
,
January 1970 in “Cell and Tissue Research” 249 citations
,
May 2003 in “Developmental Biology” Ectodysplasin-A1 is crucial for developing hair, teeth, and glands.
7 citations
,
September 2017 in “Advances in Clinical and Experimental Medicine” This study found that lanugo hair appears earlier on the posterior wall of the trunk than on the anterior wall in human fetuses, with a nearly two-week difference in development time.
15 citations
,
May 2003 in “The Laryngoscope” In this study, researchers observed that spiral ganglion neurites created more branched networks near FGF-1-coupled beads compared to control beads, highlighting FGF-1's role in hair cell innervation development.
45 citations
,
December 1991 in “Annals of the New York Academy of Sciences” This study reports that different adhesion molecules play distinct roles in the morphogenesis of feathers and hair, influencing processes such as mesenchymal condensation, epithelial folding, and cell death.
50 citations
,
September 1997 in “Developmental Biology” 55 citations
,
January 2004 in “The International Journal of Developmental Biology” This study reports that corneal transient amplifying cells can be reprogrammed into epidermal cells capable of forming hair follicles in response to embryonic dermis signals.
117 citations
,
August 1999 in “Nature Genetics” 44 citations
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May 2008 in “Acta Zoologica” This study explains how the development of keratin-associated proteins in embryonic epidermis is crucial for forming protective barriers in vertebrates, enabling them to adapt to terrestrial environments.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.
292 citations
,
October 1985 in “The Journal of Cell Biology” This study observed that the expression of certain keratins during human epidermal development marks the tissue's commitment to stratification and keratinization processes.
33 citations
,
October 2012 in “Journal of Morphology” This study identified the distribution of keratin-associated proteins during cornification in the epidermis of reptiles, revealing unique structural characteristics in sauropsid keratin proteins compared to other vertebrates.
January 2017 in “Zurich Open Repository and Archive (University of Zurich)” This study presents a new, effective method for delivering dental epithelial stem cells to the jaw, aiming to advance therapies for enamel defects and regeneration.