98 citations
,
July 1968 in “Archives of Dermatology” This study found that applying scalp sebum from young men to rabbit ear canals caused follicular hyperkeratosis, suggesting sebum stimulates the formation of comedones, a key feature in acne vulgaris.
5 citations
,
March 2019 in “Scandinavian journal of rheumatology” This article discusses the potential misdiagnosis issues in cutaneous manifestations of lupus erythematosus and reports no new research findings.
October 2018 in “Focus on surfactants” 44 citations
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January 1999 in “Dermatology” This article reviews different perspectives on nevus comedonicus, discussing its classification and potential associations with systemic findings, but it reports no new results.
38 citations
,
June 2005 in “International Journal of Dermatology” This case report describes a 28-year-old man with widespread pigmented basal cell carcinomas and recurrent infections that were challenging to control, associated with nevus comedonicus and a rudimentary toe.
21 citations
,
March 2003 in “Acta Dermato Venereologica” Tacalcitol ointment effectively improves bilateral nevus comedonicus.
14 citations
,
January 2015 in “Acta dermato-venereologica” Acitretin significantly reduced inflammatory attacks in a woman with Naevus Comedonicus Syndrome but caused side effects.
7 citations
,
January 2013 in “Ophthalmic plastic and reconstructive surgery” This case report describes a rare instance of late-onset, bilateral nevus comedonicus of the eyelids in a 79-year-old man, highlighting its clinical and histopathologic features.
2 citations
,
May 2014 in “PubMed” This case report describes a 10-year-old boy with a localized patch of partial alopecia and comedonal lesions, diagnosed as an atypical nevus comedonicus, and treated with topical tretinoin.
2 citations
,
May 1991 in “PubMed” This article reviews naevus comedonicus, highlighting potential treatments like retinoic acid application and surgical intervention, but reports no new clinical findings.
1 citations
,
December 2019 in “American journal of ophthalmology. Case reports” This case report describes an unusual occurrence of late-onset nevus comedonicus affecting both eyelids, with complications including bilateral ptosis and ectropion.
1 citations
,
January 2019 in “Dermatology Online Journal” This case report describes a rare occurrence of nevus comedonicus on the scalp of a 19-year-old woman, highlighting its unusual location and classic appearance.
1 citations
,
January 2009 In this case report, a 25-year-old man with nevus comedonicus showed no improvement from keratolytics and topical tretinoin, but had success with surgical excision of the lesions.
January 2026 in “Indian Journal of Paediatric Dermatology” In this case report, a 14-year-old boy was diagnosed with nevus comedonicus, a condition characterized by dilated follicular openings filled with keratin, presenting in a Blaschkoid pattern; treatment with topical tretinoin 0.1% cream was recommended.
August 2025 in “Kırıkkale Üniversitesi Tıp Fakültesi Dergisi” In this case study, researchers described a 47-year-old male with diabetes mellitus who developed inflammatory nevus comedonicus on his forehead, suggesting a potential link between this skin condition and diabetes. They recommend monitoring similar patients for diabetes and conducting studies to explore this association further.
January 2025 in “Indian Dermatology Online Journal” This case report describes a rare presentation of nevus comedonicus following the lines of Blaschko, treated with oral isotretinoin and other therapeutic measures, resulting in a reduction of episodic painful cystic lesions.
September 2024 in “The Journal of Dermatology” In this study, researchers reported a rare case of nevus comedonicus with hair growth in a 26-year-old male, challenging prior reports that affected lesions typically lack the capability to develop terminal hair.
November 2017 in “International journal of research in dermatology” This case report describes a rare instance of nevus comedonicus with a multi-dermatomal unilateral pattern along the lines of Blaschko, treated unsuccessfully with topical tretinoin and oral retinoids.
June 2022 in “Indian Dermatology Online Journal” This case report describes a 19-year-old male with alopecia totalis and comedones over the bald scalp, suggesting the importance of terminal hair for sebum drainage to prevent preliminary acne lesions.
138 citations
,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.
25 citations
,
October 1984 in “Journal of Clinical Investigation” This study demonstrated that human sebaceous glands can be successfully transplanted onto nude mice, where androgen stimulation increases gland volume, cell size, and labeling index.
1 citations
,
November 1999 in “Hautarzt” Finasteride is not expected to be effective for treating Acne vulgaris.
76 citations
,
October 2016 in “Clinics in dermatology” This review discusses the hormonal and genetic factors influencing acne development, emphasizing the role of androgens and insulin signaling but reports no new clinical results.
July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study used single-cell transcriptomic analysis to identify a specific cell population in acne patients' non-lesional skin, providing evidence for the comedone switch hypothesis by suggesting a shift towards infundibular differentiation at the expense of sebaceous gland maintenance.
42 citations
,
September 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the distinct clinical and psychological aspects of adult female acne and reports no new clinical results, highlighting the need for a comprehensive management approach.
56 citations
,
October 2010 in “Pediatric Clinics of North America” This article discusses various types of epidermal nevi and associated syndromes but presents no new research findings.
2 citations
,
April 2012 in “American Journal of Dermatopathology” This report describes two cases of nevus lipomatosus superficialis with the unusual feature of dilated hair follicles, emphasizing the need for precise histopathological diagnosis to differentiate from similar conditions.
1 citations
,
November 2021 in “Biomedicines” This review elaborates on the concept of cutaneous mosaicism and its link to acneiform conditions, but it reports no new clinical results.
This article discusses tretinoin, noting its approved use for acne and photoaging and its broader application in treating various dermatological conditions, but reports no new clinical findings.
This chapter offers detailed histopathologic insights into various pilosebaceous unit diseases, discussing diagnosis without reporting new results.