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    Glossary Collagen Matrix

    The collagen matrix is a structural framework composed primarily of collagen fibers that provides support and strength to various tissues, including the dermis of the skin where hair follicles reside. In the context of hair loss, the integrity of the collagen matrix is crucial, as it influences the health of hair follicles and the surrounding scalp environment. A compromised collagen matrix can lead to weakened hair follicles, contributing to conditions such as androgenetic alopecia and other forms of hair thinning. Key distinguishing characteristics include its role in maintaining skin elasticity, hydration, and overall follicular health, making it a significant factor in hair biology and loss.

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    1. Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix The Journal of Dermatology · 1990 · 36 citations
    2. Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix Experimental cell research · 2022 · 1 citations
    3. Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors Marine drugs · 2023 · 2 citations
    4. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis Frontiers in Nutrition · 2026
    5. [Three-dimensional culture of plucked human hair follicles inside the collagen gel matrix]. PubMed · 1990 · 3 citations
    6. Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions Experimental Dermatology · 2019 · 2 citations
    7. Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture British Journal of Dermatology · 1998 · 30 citations
    8. Skin equivalent containing collagen-human hair keratin matrice for formation of neodermis Jiepouxue zazhi · 2003
    9. Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing Journal of Investigative Dermatology · 2024 · 24 citations
    10. Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects Clinical, cosmetic and investigational dermatology · 2024
    11. Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix Journal of Investigative Dermatology · 1987 · 87 citations
    12. Properties of Murine Pelage Hair Follicles in Monolayer and Collagen Matrix Cultures Journal of Investigative Dermatology · 1991 · 3 citations
    13. Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix Journal of Investigative Dermatology · 2015 · 4 citations
    14. Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts Journal of Investigative Dermatology · 1995 · 11 citations
    15. Building a Better Scar: Re-engineering Extracellular Matrix Structure in Dermal Scars VTechWorks (Virginia Tech) · 2020 · 1 citations
    16. A regenerative stem cell-derived matrix accelerates functional dermal wound repair in a preclinical diabetic model 2026
    17. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    18. 877 Integration of magnetic tweezers and traction force microscopy for exploring the mechanobiology of keratinocyte cell-cell and cell-matrix anchoring junctions Journal of Investigative Dermatology · 2018
    19. Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure Scientific Reports · 2017 · 87 citations
    20. Effect of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofiber Matrices Cocultured With Hair Follicular Epithelial and Dermal Cells for Biological Wound Dressing Artificial Organs · 2007 · 64 citations
    21. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    22. Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing Theranostics · 2018 · 49 citations
    23. Distribution of Extracellular Matrix Molecules in Human Hair Follicles Annals of the New York Academy of Sciences · 1991 · 45 citations
    24. The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility Biomaterials · 2009 · 44 citations
    25. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    26. Novel ECM Patch Combines Poly(vinyl alcohol), Human Fibroblast-Derived Matrix, and Mesenchymal Stem Cells for Advanced Wound Healing ACS Biomaterials Science & Engineering · 2020 · 28 citations
    27. Cultured dermal papilla cells of the rat vibrissa follicle. Proliferative activity, adhesion properties and reorganization of the extracellular matrix in vitro Archives of Dermatological Research · 1997 · 27 citations
    28. The extracellular matrix dictates regional competence for tumour initiation Nature · 2023 · 24 citations
    29. ADSCs inhibit photoaging‐ and photocarcinogenesis‐related inflammatory responses and extracellular matrix degradation Journal of Cellular Biochemistry · 2019 · 19 citations
    30. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations