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    Glossary Collagen Matrix

    The collagen matrix is a structural framework composed primarily of collagen fibers that provides support and strength to various tissues, including the dermis of the skin where hair follicles reside. In the context of hair loss, the integrity of the collagen matrix is crucial, as it influences the health of hair follicles and the surrounding scalp environment. A compromised collagen matrix can lead to weakened hair follicles, contributing to conditions such as androgenetic alopecia and other forms of hair thinning. Key distinguishing characteristics include its role in maintaining skin elasticity, hydration, and overall follicular health, making it a significant factor in hair biology and loss.

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    1. Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix The Journal of Dermatology · 1990 · 36 citations
    2. Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture British Journal of Dermatology · 1998 · 30 citations
    3. [Three-dimensional culture of plucked human hair follicles inside the collagen gel matrix]. PubMed · 1990 · 3 citations
    4. Pulling force deforms hair follicle root sheath nuclei and surrounding dermal collagen matrix differently at infundibulum, isthmus and suprabulbar regions Experimental Dermatology · 2019 · 2 citations
    5. Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors Marine drugs · 2023 · 2 citations
    6. Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix Experimental cell research · 2022 · 1 citations
    7. Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis Frontiers in Nutrition · 2026
    8. Skin equivalent containing collagen-human hair keratin matrice for formation of neodermis Jiepouxue zazhi · 2003
    9. Type III Collagen Regulates Matrix Architecture and Mechanosensing during Wound Healing Journal of Investigative Dermatology · 2024 · 24 citations
    10. Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects Clinical, cosmetic and investigational dermatology · 2024
    11. Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix Journal of Investigative Dermatology · 1987 · 87 citations
    12. Properties of Murine Pelage Hair Follicles in Monolayer and Collagen Matrix Cultures Journal of Investigative Dermatology · 1991 · 3 citations
    13. Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix Journal of Investigative Dermatology · 2015 · 4 citations
    14. Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts Journal of Investigative Dermatology · 1995 · 11 citations
    15. Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure Scientific Reports · 2017 · 87 citations
    16. Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography Scientific Reports · 2022 · 31 citations
    17. The extracellular matrix dictates regional competence for tumour initiation Nature · 2023 · 24 citations
    18. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    19. Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles Journal of Biomedical Materials Research Part A · 2019 · 8 citations
    20. Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair BMC Biotechnology · 2024 · 5 citations
    21. Injectable hydrogel made from antler mesenchyme matrix for regenerative wound healing <i>via</i> creating a fetal-like niche World Journal of Stem Cells · 2023 · 5 citations
    22. MORPHOLOGICAL CHARACTERISTICS OF ACELLULAR DERMAL MATRIX MANUFACTURING Wiadomości Lekarskie · 2021 · 5 citations
    23. Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin International journal of molecular sciences · 2023 · 2 citations
    24. Fish Acellular Dermal Matrix Promotes Repair of Full‐Thickness Skin Defects in Mice and Bama Pigs Wound Repair and Regeneration · 2025 · 1 citations
    25. A regenerative stem cell-derived matrix accelerates functional dermal wound repair in a preclinical diabetic model 2026
    26. Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle‐Shaped Microfluidic Device 2024
    27. 973 Dipeptidyl-peptidase 4 (DPP4)-positive fibroblasts are responsible for secretion of pro-fibrotic matrix proteins in the human skin Journal of Investigative Dermatology · 2019
    28. 877 Integration of magnetic tweezers and traction force microscopy for exploring the mechanobiology of keratinocyte cell-cell and cell-matrix anchoring junctions Journal of Investigative Dermatology · 2018
    29. Biocompatibility of hair follicle stem cells and heterogeneous bladder acellular matrixat Zhonghua miniao waike zazhi · 2013
    30. Effect of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanofiber Matrices Cocultured With Hair Follicular Epithelial and Dermal Cells for Biological Wound Dressing Artificial Organs · 2007 · 64 citations