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    Did you mean Chronic Leg Ulcers?
    Glossary Chronic Leg Ulcers

    long-lasting leg sores that don't heal within six weeks

    Chronic leg ulcers are long-lasting sores or wounds on the legs that fail to heal within a typical timeframe, usually defined as six weeks or more. They are often caused by underlying conditions such as poor blood circulation, diabetes, or venous insufficiency, and can lead to significant pain, infection, and reduced quality of life if not properly managed.

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    1. Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine International Wound Journal · 2016 · 56 citations
    2. Chronic Ulceration of the Scalp Associated with Genetically Different Types of Congenital Ichthyosis: A Series of Four Cases Acta dermato-venereologica · 2020 · 1 citations
    3. Hair-follicle transplant as chronic skin ulcer treatment Portuguese Journal of Dermatology and Venereology · 2022
    4. Klinefelter syndrome and chronic leg ulcers Journal of The American Academy of Dermatology · 2009
    5. Chronic nonhealing ulcer in a finger of a toddler – a rare presentation of the hair thread tourniquet syndrome International Journal of Dermatology · 2008 · 4 citations
    6. Hair-follicle Transplant Into Chronic Ulcers: A New Graft Concept 2017 · 6 citations
    7. ORAL CHRONIC ULCER: A DIAGNOSIS CHALLENGE 2019
    8. Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells Journal of Investigative Dermatology · 1996 · 99 citations
    9. A pilot clinical study of hair grafting in chronic leg ulcers Wound Repair and Regeneration · 2012 · 63 citations
    10. Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers International Journal of Molecular Sciences · 2023 · 12 citations
    11. Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers Frontiers in Bioengineering and Biotechnology · 2023 · 14 citations
    12. Autologous smashed follicular dermal graft with epidermal cell suspension in chronic nonhealing leg ulcers Journal of Cutaneous and Aesthetic Surgery · 2020 · 3 citations
    13. The Efficacy of Local Autologous Platelet-Rich Plasma Prepared by Single and Double Spin Methods in the Treatment of Chronic Ulcer Cureus · 2024 · 2 citations
    14. Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects International Journal of Molecular Sciences · 2021 · 70 citations
    15. Desarrollo de una nueva terapia para el tratamiento de lesiones ulcerosas crónicas mediante el trasplante alogénico de una subpoblación de células madre mesenquimales derivadas de cordones umbilicales humanos 2026
    16. Platelet - Rich Plasma (PRP) and Platelet - Rich Fibrin (PRF) Clot Dressing in Chronic Wound Management: Two Case Reports International Journal of Science and Research (IJSR) · 2023
    17. Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms Cancer Research · 2019
    18. Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms Tumor Biology · 2019
    19. Human placental mesenchymal stromal cell‐derived exosome‐enriched extracellular vesicles for chronic cutaneous graft‐versus‐host disease: A case report Journal of Cellular and Molecular Medicine · 2021 · 13 citations
    20. Abstract 5202: Bone marrow-derived epithelial cells contribute to chronic skin inflammation and skin tumor formation in the mouse Cancer Research · 2012
    21. Regeneration of Chronic Wounds with Allogeneic Platelet Gel versus Hydrogel Treatment: a Prospective Study Acta Clinica Croatica · 2018 · 25 citations
    22. Skin manifestations of chronic kidney disease Actas Dermo-Sifiliográficas · 2015
    23. Do Syrian conflict survivors show novel chronic cutaneous sequelae from chlorine gas exposure: A case report and literature review Journal of International Medical Research · 2025
    24. Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report) Diseases · 2018 · 38 citations
    25. NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series Drug metabolism and drug interactions · 2020 · 10 citations
    26. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    27. Ankle Range of Motion, Leg Pain, and Leg Edema Improvement in Patients With Venous Leg Ulcers JAMA Dermatology · 2016 · 4 citations
    28. miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes Journal of Investigative Dermatology · 2020 · 90 citations
    29. Innovative Uses for Zinc in Dermatology Dermatologic Clinics · 2010 · 27 citations
    30. Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis Stem cell reviews and reports · 2022 · 7 citations