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Vitamin D3 affects cell differentiation in specific skin areas.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Neurosteroids show promise for treating epilepsy and more research is needed.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Lufenuron effectively and quickly treats fungal infections in dogs and cats without side effects.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

3% topical minoxidil effectively treats extensive alopecia areata with few side effects.

Genetically modified plants could be an important source of omega-3 fats to meet global needs.

Oral retinoids can cause side effects ranging from mild to severe, including birth defects, and require careful monitoring and contraception.

Antiandrogen treatments combined with oral contraceptives can help manage hair growth and hair loss in women with PCOS.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

Some cats with sudden hair loss and tiredness might have cancer-related alopecia.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Jojoba oil is highly valued for its diverse medicinal and industrial uses.

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

Hair analysis for drugs needs a better understanding of how drugs enter hair, considering factors like hair structure and pigmentation.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.

Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.