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Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Herbal remedies can cause adverse effects and need more safety research.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Toxic Shock Syndrome mainly affects menstruating women, can recur, and is linked to staph bacteria, with rapid treatment being crucial.

Some medicinal plants can help heal wounds and may lead to new treatments.

DrugNet effectively identifies new uses for existing drugs and may save resources in drug development.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The Protein-Sparing Modified Fast is effective for rapid weight loss and maintaining it, but requires medical supervision and can have side effects.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Vitamin D3 affects cell differentiation in specific skin areas.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.