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    Glossary Cellular Senescence

    state where cells permanently stop dividing but remain metabolically active

    Cellular senescence is a state in which cells stop dividing and enter a permanent state of growth arrest without dying. This process is a natural part of aging and acts as a defense mechanism against cancer, as it prevents damaged cells from proliferating. However, the accumulation of senescent cells over time can contribute to tissue dysfunction and age-related diseases.

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    1. Cellular senescence in skin‐related research: Targeted signaling pathways and naturally occurring therapeutic agents Aging Cell · 2023 · 48 citations
    2. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    3. Cellular Senescence and Aging in Myotonic Dystrophy International Journal of Molecular Sciences · 2022 · 4 citations
    4. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    5. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    6. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    7. Oxidative Stress and Hormone-regulated Dermal Papilla Cell-targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy Biomaterials Research · 2026
    8. Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model Journal of Photochemistry and Photobiology B Biology · 2025
    9. Targeting IGF1‐Induced Cellular Senescence to Rejuvenate Hair Follicle Aging Aging Cell · 2025
    10. The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst Research · 2025
    11. 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs Journal of Investigative Dermatology · 2024
    12. Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells iScience · 2024
    13. Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence GeroScience · 2024
    14. Protective Effect of Iris germanica L. Rhizome-Derived Exosome against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes Applied sciences · 2023
    15. 1380 Ganoderma lucidum extract attenuates Corticotropin-Releasing Factor (CRF)-induced cellular senescence in human hair follicular cells Journal of Investigative Dermatology · 2023
    16. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway Discovery medicine · 2023
    17. 520 The protective effects of Apocynin against ultraviolet B-induced cellular senescence in human keratinocytes Journal of Investigative Dermatology · 2022
    18. 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes 2022
    19. 692 Prevention of H 2 O 2 -induced cellular senescence in human hair follicle dermal papilla cells Journal of Investigative Dermatology · 2017
    20. Investigating the roles of cellular senescence in embryogenesis and aging TDX (Tesis Doctorals en Xarxa) · 2014
    21. 138: Induction of cellular senescence and hair follicle stem cell dysfunction upon p14ARF and p16Ink4a expression in the skin European Journal of Cancer · 2014
    22. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    23. 866 Senescent fibroblasts secretome promote tumoural initiation of normal human keratinocytes through cellular activation, enhanced migration and ECM remodelling European Journal of Cancer Supplements · 2010
    24. The emerging role of cellular senescence in amyotrophic lateral sclerosis Frontiers in Neuroscience · 2025 · 1 citations
    25. Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence Stem Cell Research & Therapy · 2025 · 3 citations
    26. The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle Trends in Cell Biology · 2018 · 68 citations
    27. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    28. Integrated evaluation of umbilical cord mesenchymal stromal cell-derived extracellular vesicles across skin-related cellular and zebrafish models Frontiers in Bioengineering and Biotechnology · 2026
    29. Alopecia Androgenética Feminina em Paciente Idosa: Relato de Caso com Protocolo Regenerativo Integrativo e Modulação de Senescência Zenodo (CERN European Organization for Nuclear Research) · 2025
    30. Alopecia Androgenética Feminina em Paciente Idosa: Relato de Caso com Protocolo Regenerativo Integrativo e Modulação de Senescência Zenodo (CERN European Organization for Nuclear Research) · 2025