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GlossaryCell Cycle

series of stages a cell undergoes to grow and divide

The cell cycle, also known as the cell division cycle, is the series of stages that a cell goes through to grow and divide. It consists of four main phases: G1 (cell growth), S (DNA replication), G2 (preparation for mitosis), and M (mitosis, where the cell divides into two daughter cells). This process is crucial for tissue growth, repair, and maintenance, including the regeneration of hair follicles.

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research Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling

116 citations, May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

92 citations, November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

61 citations, September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.

research A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle

38 citations, April 2016 in “Experimental Dermatology”

The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations, April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Cell Cycle Regulation and Regeneration

27 citations, January 2012 in “Current Topics in Microbiology and Immunology”

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment

25 citations, March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules

7 citations, July 2019 in “International Journal of Molecular Sciences”

PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations, February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity

4 citations, September 2020 in “Cell division”

XMU-MP-1 stops cell growth in a human mini-organ and reduces the effectiveness of the chemotherapy drug paclitaxel.

research Temporary Cell Cycle Arrest in Human Scalp Hair Follicles and Their Epithelial Stem Cells by ALRN-6924: A Novel Strategy to Selectively Protect p53-Wildtype Cells Against Paclitaxel-Induced Alopecia

1 citations, November 2022 in “Journal of Investigative Dermatology”

ALRN-6924 may prevent hair loss caused by chemotherapy.

research HX109 Herbal Extract Promotes Hair Growth by Regulating Cell Cycle in Hair Follicle Dermal Papilla Cells

March 2023 in “Asian Journal of Beauty and Cosmetology”

HX109 herbal extract helps hair grow by boosting cell growth and reducing cell death.

research Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell-Cycle Arrest and Premature Senescence in Adult Mice

February 2024 in “Journal of Investigative Dermatology”

Deleting NIPP1 in mouse skin cells causes early aging and chronic skin issues.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

research Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

May 2020 in “Research Square (Research Square)”

Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

research DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells

January 2012 in “Else Kröner-Fresenius Symposia”

Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.

research Regulatory Effect of 4-O-Methylhonokiol on TGF-β1-Induced Cell Cycle Arrest in Human Keratinocyte Cell Line (HaCaT)

August 2011 in “Planta Medica”

4-O-methylhonokiol from Magnolia Officinalis may promote hair growth by interfering with TGF-β1 effects in skin cells.

research Immune Cell Regulation of the Hair Cycle

27 citations, January 2020 in “Experimental Dermatology”

Immune cells affect hair growth and could lead to new hair loss treatments.

Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

research Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

5 citations, January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage

3 citations, July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

research Stereological Quantification of Cell-Cycle Kinetics and Mobilization of Epithelial Stem Cells During Wound Healing

1 citations, January 2016 in “Methods in molecular biology”

The method helps estimate and track skin cell growth and movement during healing.

Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

4 citations, January 2014 in “The Scientific World Journal”

Red deer antler extract helps hair grow by extending the growth phase and increasing cell growth in hair follicles.

research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

176 citations, February 2006 in “Cancer Research”

research Ginsenoside Rb1 Retards Aging Process by Regulating Cell Cycle, Apoptotic Pathway, and Metabolism of Aging Mice

28 citations, March 2020 in “Journal of ethnopharmacology”

Ginsenoside Rb1 slows down aging in mice by affecting cell growth, cell death, and metabolism.

research 12-Chloracetyl-PPD, A Novel Dammarane Derivative, Shows Anti-Cancer Activity by Delaying G2/M Phase Cell Cycle Progression and Inducing ROS-Mediated Apoptosis

18 citations, December 2016 in “European journal of pharmacology”

A new compound slows cancer cell growth and causes cell death by blocking cell cycle progression and increasing cell-damaging molecules.

research Delayed Hair Cycle in Mnd2 Mutant Mice Lacking HtrA2 Serine Protease Activity

December 2022 in “Biochemical and Biophysical Research Communications”

HtrA2 activity is crucial for normal hair growth by regulating fat cell development.

research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

45 citations, April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.

research Morroniside Regulates Hair Growth and Cycle Transition via Activation of the Wnt/β-Catenin Signaling Pathway

25 citations, September 2018 in “Scientific Reports”

Morroniside may help hair grow and stay in its growth phase by affecting certain cell signals.