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    Glossary Cell Cycle Arrest

    process that halts cell division to repair damage or stress

    Cell cycle arrest is a mechanism that stops the progression of the cell cycle, preventing cells from dividing. This can occur in response to DNA damage, lack of nutrients, or other stress signals, allowing the cell time to repair itself or, if the damage is too severe, to initiate programmed cell death (apoptosis). This process is crucial for maintaining genetic stability and preventing the proliferation of damaged cells, which can lead to diseases like cancer.

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    1. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    2. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    3. Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood Journal of Endocrinological Investigation · 2023 · 2 citations
    4. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations
    5. Intensive stress impedes hair follicle growth through triggering cell cycle arrest of hair follicle stem cells The FASEB Journal · 2025
    6. 502 The stress-responsive secretory protein adrenomedullin 2 potently induces cell cycle arrest and apoptosis in human hair follicles Journal of Investigative Dermatology · 2024
    7. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    8. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    9. Cedrol restricts the growth of colorectal cancer <i>in vitro</i> and<i> in vivo</i> by inducing cell cycle arrest and caspase-dependent apoptotic cell death International Journal of Medical Sciences · 2022
    10. Regulatory effect of 4-O-methylhonokiol on TGF-β1-induced cell cycle arrest in human keratinocyte cell line (HaCaT) Planta Medica · 2011
    11. XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity Cell division · 2020 · 4 citations
    12. B-219 Apoptotic effect and cell cycle arrest by Juniperus communis extract on oral cancer Clinical Chemistry · 2025
    13. 1367 Inhibition of the mitochondrial pyruvate carrier promotes ATF4–dependent stress responsive metabolic rewiring and cell cycle arrest in the human hair follicle 2023
    14. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures Genomics · 2010 · 61 citations
    15. Effect of Liquid Blood Concentrates on Cell Proliferation and Cell Cycle- and Apoptosis-Related Gene Expressions in Nonmelanoma Skin Cancer Cells: A Comparative In Vitro Study International Journal of Molecular Sciences · 2024
    16. Cell Cycle Regulation and Regeneration Current Topics in Microbiology and Immunology · 2012 · 27 citations
    17. p63 Regulates Human Keratinocyte Proliferation via MYC-regulated Gene Network and Differentiation Commitment through Cell Adhesion-related Gene Network Journal of Biological Chemistry · 2011 · 82 citations
    18. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation The EMBO Journal · 2016 · 29 citations
    19. Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells Biological Research · 2014 · 25 citations
    20. FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling Journal of dermatological science · 2016
    21. Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X PLOS ONE · 2017 · 18 citations
    22. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    23. Beyond goosebumps: Does the arrector pili muscle have a role in hair loss? International Journal of Trichology · 2014 · 31 citations
    24. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors Science · 2001 · 153 citations
    25. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer Breast Cancer Research and Treatment · 2016 · 59 citations
    26. Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells Pharmaceutics · 2022 · 39 citations
    27. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021 · 30 citations
    28. Effects of glucocorticoid on human dermal papilla cells in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 27 citations
    29. Effects of dihydrotestosterone on rat dermal papilla cells in vitro European Journal of Pharmacology · 2015 · 19 citations
    30. The 1,25-dihydroxyvitamin D3-independent actions of the vitamin D receptor in skin 2010 · 18 citations