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GlossaryCD200 receptor (CD200R)

protein on immune cells that regulates immune response

The CD200 receptor (CD200R) is a protein found on the surface of certain immune cells, such as macrophages and dendritic cells. It plays a crucial role in regulating the immune response by interacting with its ligand, CD200, to send inhibitory signals that help prevent excessive inflammation and autoimmunity. This interaction is important in maintaining immune tolerance and has implications in conditions like alopecia, where immune regulation is disrupted.

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Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations, February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

research In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion Using Ficus Religiosa L. and Morus Alba L.

1 citations, February 2021 in “Journal of Natural Remedies”

Ficus religiosa and Morus alba extracts improved hair growth and follicle regeneration in mice.

research Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study found that a key immune pathway protecting hair follicles is reduced in a mouse model of scarring hair loss.

research Author Response: Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity, Lessons from Alopecia Areata

September 2022

ILC1-like cells may contribute to hair loss in alopecia areata.

research Decision Letter: Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity, Lessons from Alopecia Areata

September 2022

ILC1-like cells may contribute to hair loss in alopecia areata and could be new treatment targets.

research ARQ-234: A High Affinity CD200-Fc Fusion Protein for the Treatment of Atopic Dermatitis

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

ARQ-234, a protein designed to treat atopic dermatitis, shows increased effectiveness in early testing.

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

research The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

32 citations, January 2012 in “Clinical & Developmental Immunology”

Targeting CD200 could be a new treatment for rheumatoid arthritis.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations, October 2010 in “The American Journal of Pathology”

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations, March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Cicatricial (Scarring) Alopecias: Comprehensive Review and Management

44 citations, April 2012 in “American Journal of Clinical Dermatology”

Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.

research Primary Cicatricial Alopecia: Recent Advances in Understanding and Management

44 citations, November 2011 in “The Journal of Dermatology”

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Somatostatin may help protect hair follicles from immune attacks.

research A Comparison of Transcriptomic Patterns Measured in the Skin of Chinese Fine and Coarse Wool Sheep Breeds

17 citations, October 2017 in “Scientific reports”

Fine wool sheep have more genes for wool quality, while coarse wool sheep have more for skin and muscle traits.

research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations, May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research In Vitro Identification of a Stem Cell Population from Canine Hair Follicle Bulge Region

5 citations, December 2017 in “Tissue and cell/Tissue & cell”

Researchers found stem cells in dog hair follicles using specific markers.

research Integrated-Omics Profiling Unveils the Disparities of Host Defense to ECM Scaffolds During Wound Healing in Aged Individuals

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Aged individuals heal wounds less effectively due to specific immune cell issues.

Comparative Analysis of the Clinical-Pathological and Immunopathological Characteristics of Lichen Planopilaris and Frontal Fibrosing Alopecia

research Comparative Analysis of the Clinical-Pathological and Immunopathological Characteristics of Lichen Planopilaris and Frontal Fibrosing Alopecia

April 2016

Lichen planopilaris and frontal fibrosing alopecia are likely the same disease with different clinical appearances.

Primary Scarring Alopecias: Review of Histopathological Findings of 37 Patients from the Department of Dermatology at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo from 2000 to 2005

research Primary Scarring Alopecias: Review of Histopathological Findings of 37 Patients from the Department of Dermatology at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo from 2000 to 2005

January 2011

Accurate diagnosis of cicatricial alopecias requires thorough scalp examination and multiple biopsy techniques.

research IL-17 Axis Is a Significant Driver of Skin Inflammation in CARD14 Mutant Pityriasis Rubra Pilaris Model Mice

February 2023 in “Research Square (Research Square)”

Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.

research Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles

23 citations, September 2020 in “Journal of Dermatological Science”

Targeting Vδ1+T-cells may help treat alopecia areata.

research Frontal Fibrosing Alopecia: An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

8 citations, July 2020 in “Clinical, cosmetic and investigational dermatology”

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations, December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions

61 citations, September 2010 in “Journal of Dermatological Science”

Stress hormones and autoimmune reactions can cause hair loss.

research Immune Privilege Collapse And Alopecia Development: Is Stress A Factor

51 citations, December 2017 in “Skin Appendage Disorders”

Stress may trigger hair loss by affecting immune protection in hair follicles.

research A Hairy Situation: PADIs in Regeneration and Alopecia

5 citations, December 2021 in “Frontiers in Cell and Developmental Biology”

Enzymes called PADIs play a key role in hair growth and loss.

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

4 citations, October 2022 in “Genes”

Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.

research Editor's Evaluation: Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity, Lessons from Alopecia Areata

September 2022

ILC1-like cells can independently cause alopecia areata by affecting hair follicles.

research Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

research Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

February 2024 in “International journal of molecular sciences”

Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.