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GlossaryCardiac Function

ability of the heart to pump blood throughout the body

Cardiac function, also known as heart function or cardiac performance, refers to the ability of the heart to pump blood effectively throughout the body. It encompasses various parameters such as heart rate, stroke volume (the amount of blood pumped per beat), and cardiac output (the total volume of blood pumped per minute). Proper cardiac function is crucial for delivering oxygen and nutrients to tissues and removing waste products, ensuring overall bodily health and function.

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Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

research Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

13 citations, August 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

Finasteride Effectively Attenuates the Impairments of Left Ventricular Function and Cardiac Sympathovagal Balance in Both Aging and Obese Male Rats via Reducing Systemic Oxidative Stress

research Finasteride Effectively Attenuates the Impairments of Left Ventricular Function and Cardiac Sympathovagal Balance in Both Aging and Obese Male Rats via Reducing Systemic Oxidative Stress

November 2023 in “European heart journal”

Finasteride improves heart function and balance in aging and obese male rats by reducing oxidative stress.

Corrigendum to 'Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling and Reverts Pathologic Gene-Expression After Myocardial Infarction in Mice'

research Corrigendum to 'Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling and Reverts Pathologic Gene-Expression After Myocardial Infarction in Mice'

November 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

Cardiac Flow Parameters with Conventional and Pulsed Tissue Doppler Echocardiography Imaging in Patients with Polycystic Ovary Syndrome

research Cardiac Flow Parameters with Conventional and Pulsed Tissue Doppler Echocardiography Imaging in Patients with Polycystic Ovary Syndrome

9 citations, May 2010 in “Gynecological Endocrinology”

Young women with PCOS and no other heart risk factors have normal heart function.

research Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction

56 citations, January 2015 in “Circulation”

Finasteride helps reduce heart issues and improves heart function.

research Maternal Androgen Excess Induces Cardiac Hypertrophy and Left Ventricular Dysfunction in Female Mice Offspring

21 citations, July 2019 in “Cardiovascular Research”

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

research Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression

September 2024 in “Chemico-Biological Interactions”

Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

44 citations, March 2015 in “PLOS ONE”

Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.

research Exploring Pericyte and Cardiac Stem Cell Secretome Unveils New Tactics for Drug Discovery

26 citations, December 2016 in “Pharmacology & Therapeutics”

New drugs for heart disease may be developed from molecules secreted by stem cells.

research Wnt1/β-Catenin Injury Response Activates the Epicardium and Cardiac Fibroblasts to Promote Cardiac Repair

248 citations, November 2011 in “The EMBO Journal”

Wnt1/βcatenin signaling is crucial for heart repair after injury.

research Left Ventricular Function in Patients with Polycystic Ovary Syndrome: A Doppler Echocardiographic Study

13 citations, September 2008 in “Experimental and Clinical Endocrinology & Diabetes”

Young women with PCOS without additional risk factors may have normal heart function.

research Targeting Cardiac Hypertrophy Through a Nuclear Co-Repressor

3 citations, October 2019 in “EMBO molecular medicine”

Targeting NCoR1 can help treat heart enlargement and dysfunction.

research Gender Differences in Cardiac Hypertrophy

27 citations, February 2020 in “Journal of Cardiovascular Translational Research”

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

research In-Silico Cardiac Aging Regulatory Model Including MicroRNA Post-Transcriptional Regulation

3 citations, June 2017 in “Methods”

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

research Loss of Repressor Activator Protein 1 Precipitates Cardiac Aging in Mice via p53/PPARα Signaling

April 2020 in “The FASEB Journal”

Loss of Rap1 protein speeds up heart aging in mice.

research Spironolactone

February 2024 in “Practical Diabetes”

Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.

research Stem Cell Secretome as a New Booster for Regenerative Medicine

54 citations, August 2019 in “Bioscience trends”

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

research The Circular RNA circNlgn Mediates Doxorubicin-Induced Cardiac Remodeling and Fibrosis

19 citations, June 2022 in “Molecular therapy. Nucleic acids”

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

research Emerging Roles of Sox6 in the Renal and Cardiovascular Systems

15 citations, November 2020 in “Physiological reports”

Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.

research K ATP Channels and Cardiovascular Disease

144 citations, March 2013 in “Circulation Research”

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

research Fibroblast Growth Factor-9 Activates c-Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart

17 citations, November 2015 in “Oxidative Medicine and Cellular Longevity”

Fibroblast Growth Factor-9 helps repair heart damage after a heart attack by creating new blood vessels, especially in diabetics.

research Phenotypic Variability of c.436delC DCAF17 Gene Mutation in Woodhouse-Sakati Syndrome

14 citations, March 2018 in “The American journal of case reports”

People with the same genetic mutation for Woodhouse-Sakati syndrome can have different symptoms.

research Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy

2 citations, June 2023 in “Gels”

Injectable hydrogels are becoming increasingly useful in medicine for drug delivery and tissue repair.

research Exosomes for Regeneration, Rejuvenation, and Repair

January 2018 in “Stem cells in clinical applications”

Exosomes show promise for tissue repair and regeneration with advantages over traditional cell therapies.

research A Case Report and Brief Literature Review of Klippel-Trénaunay Syndrome

May 2012 in “Research and reports in neonatology”

The newborn with Klippel-Trénaunay syndrome was healthy but needed regular check-ups for possible complications.

research Highlights From the Literature

November 2005 in “Physiology”

Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.

Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

research Fibrous Scaffolds Potentiate the Paracrine Function of Mesenchymal Stem Cells: A New Dimension in Cell-Material Interaction

182 citations, June 2017 in “Biomaterials”

Special fiber materials boost the healing properties of certain stem cells.