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    Glossary C3H/HeJ mouse model

    specific lab mice used to study immune responses and alopecia

    The C3H/HeJ mouse model is a specific strain of laboratory mice that is commonly used in scientific research. These mice have a genetic mutation that makes them resistant to certain bacterial infections, making them valuable for studying immune system responses and diseases like alopecia (hair loss). Researchers use this model to better understand how genetics and the immune system interact in various conditions.

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    Research 30 of 870

    1. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    2. Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model Cell stress & chaperones · 2011 · 29 citations
    3. Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model Veterinary Dermatology · 2009 · 23 citations
    4. Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model Cell Stress and Chaperones · 2010 · 18 citations
    5. ISID0197 - Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model 2023
    6. 197 Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model Journal of Investigative Dermatology · 2023
    7. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    8. The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results Experimental dermatology · 2008 · 59 citations
    9. 085 Autoantigen screening in C3H/HeJ mouse model of alopecia areata revealed high antigenicity of melanocyte-associated antigen epitopes 2019 · 1 citations
    10. Immunophenotypic Analysis of Alopecia Areata Progression in a C3H/HeJ Mouse Model 2258053 The Journal of Immunology · 2026
    11. Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata Lasers in Medical Science · 2011 · 81 citations
    12. ISID1108 - Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata. 2023
    13. 042 Characterization of Pathogenic CD8+ T Cells in an adoptive transfer Mouse Model of Alopecia Areata in C3H/HeJ mice Journal of Investigative Dermatology · 2025
    14. 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata 2023
    15. Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies Current Protocols · 2024
    16. Generation of autoreactive CD8 T cell in a mouse model of alopecia areata The Journal of Immunology · 2023
    17. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    18. Evaluation of Animal Models Suitable for Hair Research and Regeneration InTech eBooks · 2018 · 3 citations
    19. Alopecia areata − animal models Clinical and Experimental Dermatology · 2002 · 69 citations
    20. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle Stem Cell Research & Therapy · 2021 · 11 citations
    21. Alopecia areata Journal of The American Academy of Dermatology · 2017 · 290 citations
    22. IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans 2019 · 20 citations
    23. Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease Cell Reports · 2025 · 4 citations
    24. 35326 Exosome therapy for scalp hair growth—A review of the in vivo and in vitro evidence Journal of the American Academy of Dermatology · 2022 · 1 citations
    25. 058 The pattern of Fas and Fas ligand expression in alopecia areata Journal of Investigative Dermatology · 2024
    26. Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice JID Innovations · 2026
    27. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015 · 184 citations
    28. Alopecia Areata: Updates from the Mouse Perspective 2013 · 8 citations
    29. Development of Autoimmune Hair Loss Disease Alopecia Areata Is Associated with Cardiac Dysfunction in C3H/HeJ Mice PLOS ONE · 2013 · 18 citations
    30. A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily, High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata. PubMed · 2025