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    Did you mean Bone Morphogenetic Protein 4?
    Glossary Bone Morphogenetic Protein 4

    regulates hair follicle growth and tissue development

    Bone Morphogenetic Protein 4 (BMP4) is a protein that plays a crucial role in the development and growth of various tissues, including bone and hair follicles. It is part of the transforming growth factor-beta (TGF-β) superfamily and is involved in cellular processes such as differentiation, proliferation, and apoptosis. In the context of hair, BMP4 helps regulate the growth cycle of hair follicles and can influence conditions like alopecia.

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    1. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway Proceedings of the National Academy of Sciences · 2004 · 70 citations
    2. Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin. Bradford Scholars (University of Bradford) · 2009
    3. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    4. Implications of constitutively active bone morphogenetic protein (BMP) signaling in skin morphogenesis and skin postnatal homeostasis University of Southern California Digital Library · 2011
    5. Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) BMB Reports · 2013 · 5 citations
    6. Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways American Journal Of Pathology · 2009 · 45 citations
    7. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006 · 176 citations
    8. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes Proceedings of the National Academy of Sciences of the United States of America · 2006 · 92 citations
    9. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004 · 65 citations
    10. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations
    11. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    12. <i>Ishige sinicola</i> extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway Zeitschrift für Naturforschung C · 2019 · 4 citations
    13. Bone morphogenetic protein signaling drives rete ridge morphogenesis: a distinct epidermal appendage program Signal Transduction and Targeted Therapy · 2026
    14. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    15. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003 · 176 citations
    16. BONE MORPHOGENETIC PROTEINS ARE CRITICAL FACTORS FOR HAIR FOLLICLE EPITHELIAL –MESENCHYMAL INTERACTIONS IN ANDROGENETIC ALOPECIA 2017
    17. 255 Bone morphogenetic proteins are critical factors for hair follicle epithelial–mesenchymal interactions in androgenetic alopecia Journal of Investigative Dermatology · 2017
    18. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    19. Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin General and comparative endocrinology · 2017 · 19 citations
    20. 1360 Regulation of bmp signalling in melanogenesis, pigment transfer and melanocyte migration Journal of Investigative Dermatology · 2018
    21. BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy Experimental cell research · 2019 · 24 citations
    22. Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot Developmental biology · 2003 · 243 citations
    23. Androgens downregulate BMP2 impairing the inductive role of dermal papilla cells on hair follicle stem cells differentiation Molecular and Cellular Endocrinology · 2020 · 6 citations
    24. 592 Cross-interactions of BMP and WNT signaling pathways attenuate androgen effect on HFSC differentiation Journal of Investigative Dermatology · 2019
    25. Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling Seminars in Cell & Developmental Biology · 2012 · 300 citations
    26. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014 · 223 citations
    27. The periosteal requirement and temporal dynamics of BMP2‐induced middle phalanx regeneration in the adult mouse Regeneration · 2017 · 31 citations
    28. Cashmere growth control in Liaoning cashmere goat by ovarian carcinoma immunoreactive antigen-like protein 2 and decorin genes Asian-Australasian journal of animal sciences · 2018 · 7 citations
    29. Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways Animals · 2023 · 1 citations
    30. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025