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    Glossary Bone Morphogenetic Protein 7

    promotes bone and cartilage development and repair

    Bone Morphogenetic Protein 7 (BMP7), also known as Osteogenic Protein 1 (OP-1), is a protein that plays a crucial role in the development of bone and cartilage. It is part of the transforming growth factor-beta (TGF-β) superfamily and is involved in the regulation of cell growth, differentiation, and repair, making it important for both developmental biology and potential therapeutic applications in conditions like bone fractures and osteoarthritis.

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    1. Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells Cell and Tissue Research · 2013 · 28 citations
    2. Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface ˜The œAmerican journal of pathology · 2008 · 41 citations
    3. The relevance of collagen XVII expression in epidermal differentiation and proliferation Journal of dermatological science · 2016
    4. Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity Journal of Nanobiotechnology · 2021 · 15 citations
    5. 산사 열수추출물의 모발 성장과 모유두세포의 성장인자 유전자 발현에 대한 영향 Korean journal of acupuncture · 2017
    6. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    7. 840 Early and late matrix progenitors form the terminally differentiated cell layers of the hair follicle Journal of Investigative Dermatology · 2017
    8. 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision Journal of Investigative Dermatology · 2017
    9. PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate Animals · 2019 · 19 citations
    10. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    11. Binding Interactions of Keratin-Based Hair Fiber Extract to Gold, Keratin, and BMP-2 PloS one · 2015 · 22 citations
    12. Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles PLoS ONE · 2017 · 17 citations
    13. Investigation of Antioxidant Activity of Cynanchi Wilfordii Radix and Inhibitory Effect of 5α-reductase mRNA in Human Dermal Papilla Cells Dong-ui saengni byeongni hakoeji · 2017
    14. Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    15. Faculty Opinions recommendation of Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    16. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations
    17. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    18. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    19. CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen Genes · 2020 · 13 citations
    20. Author response: A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning 2017 · 3 citations
    21. TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling 2023
    22. Characterization and isolation of stem cell–enriched human hair follicle bulge cells ˜The œYear book of dermatology · 2007
    23. Male androgenetic alopecia is due to hair follicle stem cell inactivation Expert Review of Dermatology · 2011 · 3 citations
    24. Module-based complexity formation: periodic patterning in feathers and hairs Wiley Interdisciplinary Reviews-Developmental Biology · 2012 · 47 citations
    25. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    26. GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE Dermatologic Clinics · 1996 · 90 citations
    27. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    28. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    29. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes Proceedings of the National Academy of Sciences of the United States of America · 2006 · 92 citations
    30. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations