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    Glossary Basal Layer

    deepest epidermal layer where new skin cells form

    The Basal Layer, also known as the Stratum Basale, is the deepest layer of the epidermis, which is the outermost layer of the skin. This layer is crucial because it contains basal cells that continuously divide and push older cells towards the skin's surface, where they eventually shed. It also houses melanocytes, which produce the pigment melanin, giving skin its color and providing some protection against UV radiation.

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    Research 30 of 1000+

    1. Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy PLoS ONE · 2016 · 31 citations
    2. Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension 2002 · 177 citations
    3. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    4. Heterotypic cell contacts and basal lamina morphology during hair follicle development in the mouse: a light, scanning, and electron microscopic study at the site of tissue interaction Canadian journal of zoology · 1983 · 13 citations
    5. Basal cells in the epidermis and epidermal differentiation Research Square (Research Square) · 2021
    6. Immunohistochemical demonstration of keratins in the epidermal layers of the Malayan pangolin (Manis javanica), with remarks on the evolution of the integumental scale armour European Journal of Histochemistry · 2013 · 28 citations
    7. Contact cooling of the skin Physics in Medicine and Biology · 1999 · 92 citations
    8. BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin PLoS Genetics · 2014 · 84 citations
    9. Human stratified squamous epithelia differ in cellular fatty acid composition Journal of Dermatological Science · 2000 · 30 citations
    10. Melanocyte progenitor cells reside in human subcutaneous adipose tissue PLoS ONE · 2021 · 18 citations
    11. Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures Cell Transplantation · 2016 · 10 citations
    12. Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile ˜The œFASEB journal · 2007 · 45 citations
    13. Development, Structure, and Keratin Expression in <i>C57BL/6J</i> Mouse Eccrine Glands Veterinary pathology · 2011 · 29 citations
    14. Histochemical studies on cutaneous stem cells in human fetal skin Zhonghua shiyan waike zazhi · 2007
    15. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    16. A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes & Development · 1989 · 156 citations
    17. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017 · 105 citations
    18. Human Eccrine Sweat Gland Cells Can Reconstitute a Stratified Epidermis Journal of Investigative Dermatology · 2010 · 103 citations
    19. Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid Archives of Dermatology · 2000 · 74 citations
    20. Application of multiphoton microscopy in dermatological studies: A mini-review Journal of Innovative Optical Health Sciences · 2013 · 58 citations
    21. Aberrant expression of epidermal growth factor receptor in aural cholesteatoma The Laryngoscope · 1993 · 48 citations
    22. Significance of the S100A4 Protein in Psoriasis Journal of Investigative Dermatology · 2009 · 45 citations
    23. Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts Journal of cutaneous pathology · 2008 · 43 citations
    24. Eph/ephrin signaling in epidermal differentiation and disease Seminars in Cell & Developmental Biology · 2011 · 42 citations
    25. Epithelial expression of the hormone leptin by bovine skin European journal of histochemistry · 2019 · 18 citations
    26. The Expression of Vitamin D-Upregulated Protein 1 in Skin and its Interaction with Sciellin in Cultured Keratinocytes 2003 · 18 citations
    27. Update on Melasma—Part I: Pathogenesis Dermatology and Therapy · 2022 · 10 citations
    28. 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury Journal of Investigative Dermatology · 2018 · 1 citations
    29. Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination Development · 2026
    30. Tissue repair and stress responses of aged skin epidermis 2020