351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
June 2021 in “Research Square (Research Square)” The exact identity of skin stem cells and how skin cells differentiate is not fully known.
127 citations
,
July 2002 in “EMBO journal” Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.
2 citations
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January 2017 in “Experimental cell research” The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.
May 2018 in “Journal of Investigative Dermatology” The human skin's outer layer has more variety in cell types and development paths than previously thought.
November 2023 in “npj regenerative medicine” Skin spheroids with both outer and inner layers are key for regrowing skin patterns and hair.
14 citations
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June 2022 in “Stem cell reports” The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.
92 citations
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January 1999 in “Physics in Medicine and Biology” Skin can be cooled quickly and safely during laser treatments to protect it without affecting deeper layers.
43 citations
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June 2008 in “Journal of cutaneous pathology” Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.
December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” YAP1 is important for skin regeneration and may affect skin disorder treatments.
December 2022 in “Journal of Investigative Dermatology” Scientists found a new type of skin cell that could help with skin repair and these cells work better with a certain protein.
March 2021 in “Cell stem cell” Skin cell behavior is influenced by the tightness of nearby cells, affecting their growth and development.
May 2016 in “Journal of Investigative Dermatology” Lymphoid-specific helicase (Lsh) is crucial for skin growth, change, and healing after injury.
55 citations
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December 2014 in “Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì” Keratinocytes control how melanocytes work.
45 citations
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December 2007 in “The FASEB journal” There are two types of stem cells in rodent hair follicles, each with different keratin proteins.
25 citations
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April 1949 in “The journal of experimental zoology” Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.
18 citations
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July 2014 in “Stem cells” The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.
18 citations
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October 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” VDUP1 is found in skin and hair follicles, interacts with sciellin, and may help regulate skin cell differentiation.
11 citations
,
February 2012 in “Journal of cell science” Rac1 is essential for proper hair structure and color.
7 citations
,
August 2022 in “Nature communications” A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.
2 citations
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September 2013 in “Journal of Investigative Dermatology” Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.
May 2023 in “International journal of molecular sciences” The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.
May 2018 in “Journal of Investigative Dermatology” The protein DDX6 helps keep skin cells renewing properly by controlling the production of certain other proteins and breaking down those that cause cells to mature too quickly.
March 2018 Melanocyte transplantation can safely restore skin color, especially in stable vitiligo, but must be chosen carefully based on the disease phase.
58 citations
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September 2014 in “Journal of Innovative Optical Health Sciences” Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
5 citations
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January 2019 in “Elsevier eBooks” Current therapies cannot fully regenerate adult skin without scars; more research is needed for scar-free healing.
426 citations
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August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
105 citations
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October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
77 citations
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January 1980 in “Carcinogenesis” TPA is about 50 times more effective at promoting tumors than MZ.
57 citations
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April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D receptor is crucial for starting hair growth after birth.