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    Glossary Basal Cells

    cells in the lowest epidermal layer producing new skin cells

    Basal cells are a type of cell found in the lowest layer of the epidermis, which is the outermost layer of the skin. They are responsible for producing new skin cells, which then move up to replace older cells that are shed from the surface. In the context of hair, basal cells in the hair follicle play a crucial role in hair growth and regeneration.

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    1. Identification of the cell lineage at the origin of basal cell carcinoma Nature Cell Biology · 2010 · 351 citations
    2. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    3. Basal cell carcinoma — molecular biology and potential new therapies Journal of Clinical Investigation · 2012 · 146 citations
    4. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    5. YAP and TAZ are essential for basal and squamous cell carcinoma initiation EMBO Reports · 2018 · 76 citations
    6. Nevoid Basal Cell Carcinoma Syndrome Archives of Dermatology · 1966 · 61 citations
    7. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes & Diseases · 2019 · 31 citations
    8. Three-Dimensional Analysis of Cell Division Orientation in Epidermal Basal Layer Using Intravital Two-Photon Microscopy PLoS ONE · 2016 · 31 citations
    9. Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells Molecular Carcinogenesis · 2007 · 31 citations
    10. Discrimination between basal cell carcinoma and hair follicles in skin tissue sections by Raman micro-spectroscopy Journal of Molecular Structure · 2010 · 25 citations
    11. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations
    12. Differentiation of the basal cell epithelioma-like changes overlying dermatofibroma. Acta Dermato Venereologica · 1991 · 12 citations
    13. Evaluation of the Tolerability of Hedgehog Pathway Inhibitors in the Treatment of Advanced Basal Cell Carcinoma: A Narrative Review of Treatment Strategies American Journal of Clinical Dermatology · 2024 · 10 citations
    14. Anti‐keratin Monoclonal Antibody against Basal Cell Epithelioma Keratin: BKN‐1 The Journal of Dermatology · 1987 · 8 citations
    15. KERATIN PHENOTYPES IN BASAL-CELL CARCINOMAS OF THE SKIN International Journal of Oncology · 1993 · 7 citations
    16. Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis Cancer Prevention Research · 2010 · 5 citations
    17. Basal cell carcinoma of the scalp shows distinct features from the face in Asians Scientific Reports · 2022 · 5 citations
    18. Nevoid basal cell carcinoma syndrome. Some histologic observations on the cutaneous lesions Archives of Dermatology · 1966 · 3 citations
    19. Isolating subpopulations of human epidermal basal cells based on polyclonal serum against trypsin-resistant CSPG4 epitopes Experimental cell research · 2016 · 2 citations
    20. Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice International journal of molecular sciences · 2020 · 1 citations
    21. Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle UHOD : Uluslararası hematoloji - onkoloji dergisi · 2011 · 1 citations
    22. Basal cells in the epidermis and epidermal differentiation Research Square (Research Square) · 2021
    23. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis The Journal of Cell Biology · 2025
    24. Analysis of 1,25-Dihydroxyvitamin D3 Receptors (VDR. in Basal Cell Carcinomas ˜The œAmerican journal of pathology · 1999 · 42 citations
    25. Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease Cell Reports · 2022 · 14 citations
    26. Single cell transcriptomics of human epidermis reveals basal stem cell transition states bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    27. A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy Nature · 2018 · 105 citations
    28. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    29. Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma PloS one · 2014 · 15 citations
    30. Human basal cell carcinoma: the induction of anagen hair follicle differentiation Clinical and experimental dermatology · 2019 · 3 citations