62 citations
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October 2017 in “JAMA facial plastic surgery” This study reported that using condensed nanofat combined with fat grafts significantly improved the aesthetic and functional aspects of atrophic facial scars in 20 patients, as assessed by both patients and plastic surgeons using the Patient and Observer Scar Assessment Scale.
October 2025 in “Dermatology Practical & Conceptual” Dermatoscopy helps track scar changes and guide treatment.
February 2024 in “Pediatric Dermatology” In this case report, the researchers identified pathogenic compound heterozygous mutations in a young girl with lipoid proteinosis, noting her relatively mild symptoms and recommending genetic testing for early diagnosis and management of this rare condition.
April 2026 in “Biomedical Research and Therapy” This study found that certain genetic variants, specifically CYB5R1 and IL1A, may be linked to different types of acne scarring, with CYB5R1 associated with atrophic scarring and IL1A with fibrotic scarring, indicating a potential polygenic nature of acne scarring.
October 2021 in “The Egyptian Journal of Hospital Medicine ” This study concluded that combination therapies often yield better results for treating atrophic post-acne scars than single treatments.
51 citations
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September 2013 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that fractional radiofrequency microneedle treatment was safe and effective for improving acne scars in Asians, with minimal adverse effects reported at 6-month follow-up.
February 2024 in “Australasian journal of dermatology” This study found that in atrophic acne scars, inflammation infiltrates the pilosebaceous unit over time, affecting resident stem cells and hindering the normal regeneration of the epidermis and adnexal structures, leading to scarring.
April 2023 in “Journal of Investigative Dermatology” In this study, Nd:YAG picosecond lasers using fractional micro-lens array were found to have a comparable effect to ablative fractional Er:YAG lasers in treating atrophic acne scars, with better safety profiles but slightly less patient satisfaction.
106 citations
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January 2016 in “Journal of Cosmetic Dermatology” This study found that adding platelet-rich plasma to microneedling improved outcomes for atrophic acne scars more than microneedling alone, according to both quantitative and qualitative assessments.
36 citations
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November 2011 in “Journal of the European Academy of Dermatology and Venereology” This study identified distinct microscopic characteristics of acne scars, including inflammatory infiltrates and insufficient collagen deposition, suggesting that treatment should consider these histopathological findings and employ combination therapy.
16 citations
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September 2019 in “Aesthetic Plastic Surgery” Platelet-rich plasma therapy helps improve atrophic acne scars.
1 citations
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August 2024 in “Journal of Cutaneous and Aesthetic Surgery” In this study, 65% TCA showed better improvement for acne scars compared to 50% GA, but GA may be a safer alternative with fewer adverse effects.
1 citations
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December 2022 in “Archives of Dermatological Research” This study compared fluid PRF and PRP for treating atrophic acne scars and found PRF to be more effective, particularly when combined with needling. Both treatments improved scars, but PRF showed higher therapeutic response, suggesting it as a superior alternative for acne scar treatment.
March 2026 in “Frontiers in Cell and Developmental Biology” This meta-analysis found that autologous cell-based therapies, especially stromal vascular fraction, significantly improved atrophic acne scars over control treatments, enhancing both clinical and patient-reported outcomes.
January 2025 in “Dermatologic Therapy” In this study, treatment with fractional CO2 laser combined with recombinant humanized type III collagen led to significantly better improvements in atrophic acne scars compared to laser treatment with saline, attributed to collagen upregulation and MAPK pathway activation in human dermal fibroblasts.
February 2019 in “International journal of research in dermatology” This study found that a combination therapy of subcision, micro-needling, and TCA CROSS led to significant improvement in atrophic acne scars, with many patients showing improved scar grades over the treatment period.
July 2026 in “Lasers in Medical Science” In this study, the Peninsula Timerevert Needle was found to provide effective treatment for skin photoaging and acne scars with less pain and shorter treatment duration compared to EndyMed, although it caused more bleeding.
January 2026 in “International Journal of Health Science” In this pilot study, patients with atrophic acne scars experienced clinical improvements and high satisfaction after receiving three biweekly microinfusions of human insulin into their skin.
June 2024 in “IP Indian journal of clinical and experimental dermatology” This study reports that platelet-rich plasma therapy significantly improved hair regrowth in alopecia areata and reduced the severity of atrophic acne scars over six months, with generally mild side effects.
1 citations
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April 2023 in “The Egyptian Journal of Hospital Medicine” This review found that combining platelet-rich plasma with microneedling may enhance recovery and reduce toxicity in treating atrophic post-acne scars.
4 citations
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September 2019 in “Journal of The American Academy of Dermatology” This study found that combining platelet-rich plasma with microneedling or fractional CO2 laser therapy was more effective in treating postacne atrophic scars than using these therapies alone, also boosting patient satisfaction.
2 citations
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September 2019 in “Dermatologic Surgery” This retrospective study observed that hair grafting in burn and postskin graft scars, which preserve deeper skin layers, had more favorable outcomes than in scars extending to the subcutaneous layer.
1 citations
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April 2022 in “Journal of cosmetic dermatology” This study found that Krox20 is overexpressed in scar fibroblasts and may play a role in scar formation by upregulating genes involved in tissue remodeling and wound healing.
September 2023 in “International journal of biomedicine” This review evaluated current evidence on minoxidil's potential to treat scars and reported reduced collagen accumulation and fibrosis in various studies, suggesting its antifibrotic effects may benefit wound healing; however, direct studies on acne scars are yet to be conducted.
7 citations
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February 2022 in “Frontiers in Medicine” This study found that combining microneedling with PRP was more effective than microneedling alone for improving acne scars, with higher patient satisfaction and no significant increase in severe side effects.
2 citations
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January 2022 in “Journal of Cutaneous and Aesthetic Surgery” This study suggests the mechanical effect of injecting a solution is more important than the solution's nature in treating atrophic acne scars, with UBM sonography proposed for objective assessment.
1 citations
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January 2023 in “The Egyptian Journal of Hospital Medicine” This study found that combining platelet-rich plasma with microneedling and subcision was effective in treating atrophic acne scars in over 80% of patients with minimal adverse effects.
May 2021 in “Benha Journal of Applied Sciences” This study found that platelet-rich plasma injections led to significant improvements in atrophic acne scars on the treated side of participants' faces compared to the untreated side.
August 2026 in “Clinical Cosmetic and Investigational Dermatology” In this study, combining Polynucleotides High Purification Technology with hyaluronic acid significantly reduced atrophic post-acne scar areas and improved Goodman-Baron scores in a majority of treated patients over six months, reaffirming the approach's beneficial effects in a real-world outpatient setting.
108 citations
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August 2017 in “Clinical, Cosmetic and Investigational Dermatology” This review highlights microneedling's promise as an adjuvant therapy for enhanced drug delivery in dermatology, especially for conditions like atrophic scars and pigmentation disorders, though its efficacy for vitiligo is limited.