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    Did you mean 5-alpha-reductase inhibitor?
    Glossary 5-alpha-reductase inhibitor

    blocks enzyme converting testosterone to dihydrotestosterone (DHT)

    A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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    1. The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease Experimental Neurology · 2017 · 15 citations
    2. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    3. Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature Archivio Italiano di Urologia e Andrologia · 2020 · 14 citations
    4. Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function Current Urology Reports · 2014 · 11 citations
    5. Analysis of breast health outcomes in women on oral 5-alpha reductase inhibitors: A single-center retrospective cohort study Journal of the American Academy of Dermatology · 2024 · 6 citations
    6. The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs). Clinical Epidemiology · 2021 · 6 citations
    7. Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment 2015 · 4 citations
    8. IsoPSA Performance Characteristics are Unaffected by 5-Alpha Reductase Inhibitors or Alpha-Blockers: Results From the IsoPSA Validation Study Urology · 2023 · 2 citations
    9. Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia Clinical Breast Cancer · 2019 · 1 citations
    10. No Increased Cardiovascular Hazard with Oral 5-Alpha-Reductase Inhibitors in Treatment of Androgenetic Alopecia: A TriNetX Retrospective Cohort Study Journal of the American Academy of Dermatology · 2026
    11. Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement Postgraduate Medicine · 2026
    12. Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data Open Science Framework · 2026
    13. Do Alpha-Blockers and 5-Alpha Reductase Inhibitors Increase Dementia Risk? A Network Meta-analysis International Neurourology Journal · 2025
    14. Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves Molecules · 2025
    15. Using 5 alpha reductase inhibitors safely: What primary care physicians need to know Journal of Family Medicine and Primary Care · 2024
    16. Evaluating 5 alpha reductase inhibitors for the treatment of male androgenic alopecia Expert Opinion on Pharmacotherapy · 2023
    17. 5 Alpha-Reductase Inhibitor Definitions · 2020
    18. Alpha Blocker and 5-Alpha Reductase Inhibitor Prescribing Habits among Urologists and Primary Care Physicians Urology Practice · 2019
    19. Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study Mendeley Data · 2026
    20. Reduced Prostate Cancer Risk in Patients with Androgenetic Alopecia Using 5-Alpha Reductase Inhibitors: A TriNetX Real-World Cohort Study Mendeley Data · 2025
    21. Depression risk of 5-alpha reductase inhibitors: A systematic review and meta-analysis with a focus on comparator groups medRxiv (Cold Spring Harbor Laboratory) · 2025
    22. MP09-16 5-ALPHA REDUCTASE INHIBITORS FOR MALE LOWER URINARY TRACT SYMPTOMS: A COCHRANE SYSTEMATIC REVIEW AND META-ANALYSIS 2017
    23. Contraindicated use of 5-alpha-reductase inhibitors in women British Journal of Clinical Pharmacology · 2016 · 2 citations
    24. New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors. Chemical & Pharmaceutical Bulletin · 2001 · 22 citations
    25. Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell Scientific reports · 2019 · 13 citations
    26. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    27. Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor. PubMed · 1995 · 7 citations
    28. Effects of Solvent System and Storage Condition on Chemical Stability of 5(alpha)-Reductase Inhibitor Compounds in Tectona grandis L.f. Leaf Extracts Trends in Sciences · 2024
    29. 5-alpha reductase inhibitors: New evidences on benefits and harms beyond benign prostatic hyperplasia Actas urológicas españolas · 2018
    30. Screen steroid 5 alpha-reductase inhibitors in vitro by high performance liquid chromatography Fuzhou daxue xuebao. Ziran kexue ban · 2005