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    Glossary Alopecia Areata Mouse Model

    genetically modified mice used to study autoimmune hair loss

    The Alopecia Areata Mouse Model is a laboratory tool used to study alopecia areata, an autoimmune condition that causes hair loss. Researchers use genetically modified or specially bred mice that develop symptoms similar to human alopecia areata, allowing them to investigate the disease's mechanisms and test potential treatments.

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    1. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    2. Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model Veterinary Dermatology · 2009 · 23 citations
    3. Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies Current Protocols · 2024
    4. Heat treatment increases the incidence of alopecia areata in the C3H/HeJ mouse model Cell Stress and Chaperones · 2010 · 18 citations
    5. Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model Cell stress & chaperones · 2011 · 29 citations
    6. ISID0197 - Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model 2023
    7. 197 Quantitative analysis of hair loss in mice utilizing imageJ improves the efficacy evaluation of alopecia areata induction in the C3H/HeJ mouse model Journal of Investigative Dermatology · 2023
    8. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    9. Dermal lymphatic dilation in a mouse model of alopecia areata Experimental and molecular pathology · 2016 · 5 citations
    10. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012 · 75 citations
    11. The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results Experimental dermatology · 2008 · 59 citations
    12. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    13. Reversal of alopecia areata in a mouse model of human hair loss by daily dietary administration of a proprietary extract of North American ginseng (Panax Quinquefolius) 2015
    14. 085 Autoantigen screening in C3H/HeJ mouse model of alopecia areata revealed high antigenicity of melanocyte-associated antigen epitopes 2019 · 1 citations
    15. Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata British Journal of Dermatology · 2019 · 5 citations
    16. Generation of autoreactive CD8 T cell in a mouse model of alopecia areata The Journal of Immunology · 2023
    17. Restoration of hair growth with topical diphencyprone in mouse and rat models of alopecia areata Journal of the American Academy of Dermatology · 2003 · 12 citations
    18. Mesenchymal Stem Cell Therapy in Alopecia Areata: Visual and Molecular Evidence from a Mouse Model International Journal of Molecular Sciences · 2024
    19. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002 · 114 citations
    20. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018 · 45 citations
    21. Effects of the Lexington LaserComb on hair regrowth in the C3H/HeJ mouse model of alopecia areata Lasers in Medical Science · 2011 · 81 citations
    22. Immunophenotypic Analysis of Alopecia Areata Progression in a C3H/HeJ Mouse Model 2258053 The Journal of Immunology · 2026
    23. 042 Characterization of Pathogenic CD8+ T Cells in an adoptive transfer Mouse Model of Alopecia Areata in C3H/HeJ mice Journal of Investigative Dermatology · 2025
    24. LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model 2021
    25. The investigation of selective sphingosine-1 phosphate receptor 1&4 modulator to treat alopecia areata mouse model The Journal of Immunology · 2023 · 2 citations
    26. The investigation of selective sphingosine-1 phosphate receptor 1&4 modulator to treat alopecia areata mouse model 2881 The Journal of Immunology · 2025
    27. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    28. A Single Subcutaneous Dose of BMD-1141 Stimulates Hair Regrowth Comparable to Daily, High-Dose Ruxolitinib in a Mouse Model of Alopecia Areata. PubMed · 2025
    29. ISID1108 - Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata. 2023
    30. 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata 2023