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    Glossary Keratin

    protein forming hair, nails, and skin's outer layer

    Keratin is a type of protein that forms the structural foundation of hair, nails, and the outer layer of skin. It provides strength and protection, making these tissues resilient and less prone to damage. In hair, keratins are essential for maintaining its integrity and elasticity, and they play a crucial role in the hair's overall health and appearance.

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    1. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    2. Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins. 1986 · 356 citations
    3. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. The Journal of Cell Biology · 1982 · 277 citations
    4. Keratins of the Human Hair Follicle International review of cytology · 2005 · 276 citations
    5. The Catalog of Human Hair Keratins 1999 · 235 citations
    6. Human Hair Keratin‐Associated Proteins (KAPs) International review of cytology · 2006 · 226 citations
    7. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018 · 211 citations
    8. The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells Development · 2006 · 207 citations
    9. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    10. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    11. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000 · 149 citations
    12. Human keratin hydrogels support fibroblast attachment and proliferation in vitro Cell and Tissue Research · 2012 · 143 citations
    13. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    14. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter in Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993 · 133 citations
    15. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002 · 132 citations
    16. Expression of hair-related keratins in a soft epithelium: Subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation Experimental Cell Research · 1989 · 128 citations
    17. Keratin expression in basal cell carcinomas British Journal of Dermatology · 1992 · 128 citations
    18. Chapter 2 The Human Keratin Genes and Their Differential Expression 1987 · 126 citations
    19. Keratin expression in the normal nail unit: markers of regional differentiation British Journal of Dermatology · 2000 · 119 citations
    20. Human hair keratin and its-based biomaterials for biomedical applications 2014 · 115 citations
    21. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    22. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed British Journal of Dermatology · 2004 · 110 citations
    23. Tunable Keratin Hydrogels for Controlled Erosion and Growth Factor Delivery Biomacromolecules · 2015 · 106 citations
    24. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    25. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    26. The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis PLoS Genetics · 2012 · 99 citations
    27. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    28. Wool Keratin-Associated Protein Genes in Sheep—A Review Genes · 2016 · 98 citations
    29. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    30. Regulation of Keratin Gene Expression in Hair Follicle Differentiation<sup>a</sup> Annals of the New York Academy of Sciences · 1991 · 98 citations