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    Glossary Keratin

    protein forming hair, nails, and skin's outer layer

    Keratin is a type of protein that forms the structural foundation of hair, nails, and the outer layer of skin. It provides strength and protection, making these tissues resilient and less prone to damage. In hair, keratins are essential for maintaining its integrity and elasticity, and they play a crucial role in the hair's overall health and appearance.

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    1. The human keratins: biology and pathology Histochemistry and Cell Biology · 2008 · 1398 citations
    2. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    3. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003 · 561 citations
    4. A Review of Keratin-Based Biomaterials for Biomedical Applications Materials · 2010 · 517 citations
    5. Keratin cytoskeletons in epithelial cells of internal organs Proceedings of the National Academy of Sciences · 1979 · 482 citations
    6. Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage Journal of Cell Science · 1996 · 441 citations
    7. Keratins in health and cancer: more than mere epithelial cell markers Oncogene · 2010 · 438 citations
    8. Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons Proceedings of the National Academy of Sciences · 2005 · 419 citations
    9. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    10. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages during Skin Development The Journal of Cell Biology · 1998 · 318 citations
    11. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Biomaterials · 2007 · 309 citations
    12. Expression of epidermal keratins and filaggrin during human fetal skin development. The Journal of Cell Biology · 1985 · 292 citations
    13. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. The Journal of Cell Biology · 1982 · 277 citations
    14. Keratins of the Human Hair Follicle International review of cytology · 2005 · 276 citations
    15. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001 · 272 citations
    16. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    17. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins. Journal of Investigative Dermatology · 1989 · 238 citations
    18. The Catalog of Human Hair Keratins 1999 · 235 citations
    19. Location and phenotype of human adult keratinocyte stem cells of the skin Differentiation · 2004 · 233 citations
    20. The role of keratin proteins and their genes in the growth, structure and properties of hair Birkhäuser Basel eBooks · 1997 · 228 citations
    21. Human Hair Keratin‐Associated Proteins (KAPs) International review of cytology · 2006 · 226 citations
    22. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    23. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    24. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000 · 215 citations
    25. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018 · 211 citations
    26. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999 · 198 citations
    27. Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. The Journal of Cell Biology · 1989 · 198 citations
    28. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019 · 192 citations
    29. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    30. Keratin gene mutations in disorders of human skin and its appendages Archives of Biochemistry and Biophysics · 2010 · 185 citations