Search
for

    Did you mean 5-alpha-reductase inhibitor?
    Glossary 5-alpha-reductase inhibitor

    blocks enzyme converting testosterone to dihydrotestosterone (DHT)

    A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

    Related Terms

    Sort by

    Research 30 of 1000+

    1. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    2. The Risks and Benefits of 5α-Reductase Inhibitors for Prostate-Cancer Prevention 2011 · 147 citations
    3. A New Look at the 5?-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006 · 137 citations
    4. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012 · 124 citations
    5. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017 · 90 citations
    6. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008 · 78 citations
    7. Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation Expert Opinion on Drug Safety · 2012 · 71 citations
    8. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta) Teratology · 1997 · 67 citations
    9. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    10. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016 · 57 citations
    11. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
    12. 5 Alpha-reductase inhibitors: whatʼs new? Current opinion in urology · 2003 · 47 citations
    13. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    14. 5-α-Reductase inhibitors for prostate cancer chemoprevention: an updated Cochrane systematic review BJUI · 2010 · 44 citations
    15. 5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia Journal of The European Academy of Dermatology and Venereology · 2020 · 36 citations
    16. Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review Sexual medicine reviews · 2013 · 35 citations
    17. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018 · 35 citations
    18. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    19. <i>Curcuma aeruginosa</i>, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study Journal of Dermatological Treatment · 2011 · 34 citations
    20. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. The Journal of Clinical Endocrinology and Metabolism · 1992 · 34 citations
    21. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. The Journal of Clinical Endocrinology and Metabolism · 1994 · 33 citations
    22. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016 · 33 citations
    23. Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review. PubMed · 2016 · 32 citations
    24. Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride The Journal of Urology · 2013 · 32 citations
    25. Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men. The Journal of Clinical Endocrinology and Metabolism · 1992 · 30 citations
    26. Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink BMJ · 2016 · 30 citations
    27. Incomplete Recovery of Erectile Function in Rat after Discontinuation of Dual 5‐Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012 · 29 citations
    28. 12 Treatment of hirsutism with 5α-reductase inhibitors Clinics in endocrinology and metabolism · 1986 · 28 citations
    29. Long-term use of 5α-reductase inhibitors and the risk of male breast cancer Cancer Causes & Control · 2014 · 28 citations
    30. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations