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    Did you mean 5-alpha-reductase inhibitor?
    Glossary 5-alpha-reductase inhibitor

    blocks enzyme converting testosterone to dihydrotestosterone (DHT)

    A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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    1. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008 · 78 citations
    2. Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation Expert Opinion on Drug Safety · 2012 · 71 citations
    3. Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta) Teratology · 1997 · 67 citations
    4. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    5. 5 Alpha-reductase inhibitors: whatʼs new? Current opinion in urology · 2003 · 47 citations
    6. 5‐alpha‐reductase inhibitors are associated with reduced frequency of COVID‐19 symptoms in males with androgenetic alopecia Journal of The European Academy of Dermatology and Venereology · 2020 · 36 citations
    7. Side Effects of 5‐Alpha Reductase Inhibitors: A Comprehensive Review Sexual medicine reviews · 2013 · 35 citations
    8. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018 · 35 citations
    9. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. The Journal of Clinical Endocrinology and Metabolism · 1992 · 34 citations
    10. Clinical and hormonal effects of the 5 alpha-reductase inhibitor finasteride in idiopathic hirsutism. The Journal of Clinical Endocrinology and Metabolism · 1994 · 33 citations
    11. Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016 · 33 citations
    12. Adverse Effects and Safety of 5-alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review. PubMed · 2016 · 32 citations
    13. Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men. The Journal of Clinical Endocrinology and Metabolism · 1992 · 30 citations
    14. Incomplete Recovery of Erectile Function in Rat after Discontinuation of Dual 5‐Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012 · 29 citations
    15. Effects of finasteride, a 5 alpha-reductase inhibitor, on circulating androgens and gonadotropin secretion in hirsute women. The Journal of Clinical Endocrinology and Metabolism · 1994 · 22 citations
    16. New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors. Chemical & Pharmaceutical Bulletin · 2001 · 22 citations
    17. A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia Clinical endocrinology · 2014 · 22 citations
    18. 5‐alpha‐reductase inhibitor treatment for frontal fibrosing alopecia: an evidence‐based treatment update 2018 · 21 citations
    19. Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia Annals of Dermatology · 2016 · 19 citations
    20. Efficacy and safety of 5 alpha-reductase inhibitor monotherapy in patients with benign prostatic hyperplasia: A meta-analysis PLOS ONE · 2018 · 19 citations
    21. 5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety Dermatologic Therapy · 2020 · 19 citations
    22. The risk of dementia with the use of 5 alpha reductase inhibitors Journal of the neurological sciences · 2017 · 18 citations
    23. Persistent Erectile Dysfunction after Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment The World Journal of Men s Health · 2018 · 17 citations
    24. The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease Experimental Neurology · 2017 · 15 citations
    25. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    26. Role of 5 alpha-reductase inhibitors in the management of prostate cancer Clinical interventions in aging · 2006 · 15 citations
    27. Efficacy and safety of Finasteride (5 alpha-reductase inhibitor) monotherapy in patients with benign prostatic hyperplasia: A critical review of the literature Archivio Italiano di Urologia e Andrologia · 2020 · 14 citations
    28. Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell Scientific reports · 2019 · 13 citations
    29. Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors Chemical and Pharmaceutical Bulletin · 2005 · 13 citations
    30. May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications? Medical hypotheses · 2020 · 12 citations