Collagen gel contraction in hair follicle culture is mainly influenced by the amounts of collagen, dermal papilla cells, and epithelium cells.
January 2009 in “Journal of Jilin University” This study found that epithelial stem cells from plucked hair follicles grow optimally when cultured on 3T3 fibroblasts feeders.
August 1994 in “Toxicology in Vitro” This study standardized a reproducible three-dimensional human skin model for testing skin tumor promoters, using methods that do not require human skin sourcing.
June 2020 in “Journal of Investigative Dermatology” This study found that human hair follicle dermal papilla cells and keratinocytes self-assembled differently in 3D spheroid co-cultures, providing insights into cell distribution and organogenesis during skin regeneration.
January 2013 in “Journal of Tissue Engineering and Reconstructive Surgery” This study found that inserting isolated hair follicle units into engineered dermis promoted differentiation and maturation of tissue-engineered skin, maintaining hair follicle morphology and generating skin appendages like sebaceous glands.