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GlossaryRapamycin (Rapamune)

drug that inhibits mTOR to suppress immune response

Rapamycin, also known as Sirolimus, is a drug originally discovered in soil bacteria from Easter Island. It is primarily used as an immunosuppressant to prevent organ transplant rejection and has shown potential in extending lifespan and treating certain diseases by inhibiting a protein called mTOR, which regulates cell growth and metabolism.

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learn Rapamycin

mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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research Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion by Inhibiting Autophagy in Endometrial Stromal Cells

52 citations , September 2020 in “Cell Death and Disease”

Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.

research Cutaneous Toxicities From Transplantation-Related Medications

14 citations , April 2017 in “American Journal of Transplantation”

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations , June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Acne Keloidalis Nuchae in Renal Transplant Patients Receiving Tacrolimus and Sirolimus

6 citations , April 2016 in “Australasian journal of dermatology”

Renal transplant patients on tacrolimus and sirolimus may develop acne keloidalis nuchae.

research Tacrolimus-Associated Hemolytic Uremic Syndrome in a Pediatric Liver Transplant Recipient

1 citations , February 2020 in “Journal of the Canadian Association of Gastroenterology”

An 8-year-old boy developed a rare condition after a liver transplant, which improved after changing his medication.

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