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Serenoa repens may cause early puberty and should be used cautiously in children.

Spironolactone can reduce hair growth and testosterone in hirsutism, but is less effective than combined treatments.

Ovulation inhibitors effectively treat menstrual issues and improve fertility but can have side effects.

Metformin helps improve menstrual irregularities and some hormone levels in PCOS patients, but not symptoms like excess hair, acne, or hair loss.

Women with acromegaly often have irregular periods due to hormone imbalances and growth hormone effects.