Unusual Presentation with Polymenorrhagia and Markedly High 17-Hydroxy Progesterone Levels in a Woman with Non-Classic Congenital Adrenal Hyperplasia

    August 2015 in “ PubMed ”
    Azra Rizwan, Marium Hayat
    TLDR A woman with non-classic CAH had unusual heavy periods and high hormone levels, improved with treatment.
    This case study described an Asian female with non-classic congenital adrenal hyperplasia (CAH) who presented with the unusual symptom of polymenorrhagia, alongside increased body hair growth and clitoromegaly. Despite normal adrenal glands and polycystic ovaries observed via ultrasonography, she had elevated serum testosterone and 17-hydroxyprogesterone levels. An adrenocorticotropic hormone stimulation test indicated borderline cortisol deficiency. Treatment with oral dexamethasone over six months led to improvement in symptoms, although hirsutism and clitoromegaly remained unchanged. The case was notable for its rare presentation of polymenorrhagia and unexpectedly high 17-hydroxyprogesterone levels in non-classic CAH.
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