Unusual Presentation with Polymenorrhagia and Markedly High 17-Hydroxy Progesterone Levels in a Woman with Non-Classic Congenital Adrenal Hyperplasia

    August 2015 in “ PubMed ”
    Azra Rizwan, Marium Hayat
    TLDR A woman with non-classic CAH had unusual heavy periods and high hormone levels, improved with treatment.
    This case report described an unusual presentation of non-classic congenital adrenal hyperplasia (NCAH) in an Asian female who experienced polymenorrhagia since menarche, along with increased body hair growth and clitoromegaly over 7-8 years. Despite normal adrenal glands and polycystic ovaries observed via ultrasonography, the patient exhibited elevated serum testosterone and 17-hydroxyprogesterone levels. An adrenocorticotropic hormone stimulation test indicated borderline cortisol deficiency. Treatment with oral dexamethasone led to improvement in symptoms after 6 months, although hirsutism and clitoromegaly remained unchanged. The case was notable for its rare presentation with polymenorrhagia and unexpectedly high 17-hydroxyprogesterone levels in NCAH.
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