Unusual Presentation with Polymenorrhagia and Markedly High 17-Hydroxy Progesterone Levels in a Woman with Non-Classic Congenital Adrenal Hyperplasia
August 2015
in “
PubMed
”
Studysummary This case study reports an Asian female with congenital adrenal hyperplasia presenting atypically with polymenorrhagia, who showed improvement with oral dexamethasone, despite no change in hirsutism or clitoromegaly. Our plain-language summary of this paper — not a Tressless recommendation.
This case report described an unusual presentation of non-classic congenital adrenal hyperplasia (NCAH) in an Asian female who experienced polymenorrhagia since menarche, along with increased body hair growth and clitoromegaly over 7-8 years. Despite normal adrenal glands and polycystic ovaries observed via ultrasonography, the patient exhibited elevated serum testosterone and 17-hydroxyprogesterone levels. An adrenocorticotropic hormone stimulation test indicated borderline cortisol deficiency. Treatment with oral dexamethasone led to improvement in symptoms after 6 months, although hirsutism and clitoromegaly remained unchanged. The case was notable for its rare presentation with polymenorrhagia and unexpectedly high 17-hydroxyprogesterone levels in NCAH.
