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GlossaryPolycomb Repressive Complex 2

regulates gene expression by modifying chromatin structure

Polycomb Repressive Complex 2 (PRC2) is a group of proteins that play a crucial role in regulating gene expression by modifying chromatin, the material that makes up chromosomes. PRC2 adds a specific chemical mark to histones (proteins around which DNA is wrapped), leading to the repression of genes that are not needed at certain times or in certain cell types. This process is essential for proper development and cellular differentiation.

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Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

research Catalytic-Dependent and -Independent Activities of Polycomb Repressive Complex 1 Differentially Regulate Skin Stem Cell Specification

April 2017 in “Journal of Investigative Dermatology”

PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.

research Polycomb Repressive Complex 2 in Adult Hair Follicle Stem Cells Is Dispensable for Hair Regeneration

6 citations, December 2021 in “PLoS Genetics”

Polycomb Repressive Complex 2 is not needed for hair regeneration.

research PRC1 Fine-Tunes Gene Repression and Activation to Safeguard Skin Epithelium Development and Stem Cell Specification

1 citations, April 2018 in “Journal of Investigative Dermatology”

PRC1 is essential for proper skin development and stem cell formation by controlling gene activity.

research Epigenetic Control of Adult Stem Cell Function

179 citations, July 2016 in “Nature Reviews Molecular Cell Biology”

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

research Tailored Chromatin Modulation to Promote Tissue Regeneration

10 citations, May 2019 in “Seminars in Cell & Developmental Biology”

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

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