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research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

823 citations , February 1998 in “Analytical Chemistry”

Method detects finasteride in plasma at very low concentrations.

research Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride.

4 citations , January 2001 in “PubMed”

This study found that delmadinone acetate and finasteride caused a reversible suppression of prostate gland activity in male dogs, with delmadinone acetate also temporarily altering epididymal sperm maturation.

research Determination of Finasteride in Human Plasma by LC-MS and Study on its Bioequivalent

January 2007 in “Pharmaceutical Journal of Chinese People's Liberation Army”

In this study, the researchers found that two formulations of finasteride tablets were bioequivalent in Chinese healthy male volunteers.

research Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial

11 citations , October 2021 in “Journal of The European Academy of Dermatology and Venereology”

This study found that topical finasteride significantly increased hair count in men with androgenetic alopecia compared to placebo while maintaining similar efficacy to oral finasteride but with lower systemic exposure and a reduced impact on serum DHT levels, potentially minimizing sexual side effects.

research Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride

1 citations , October 2023 in “Journal of personalized medicine”

In this study, researchers investigated genetic variants in pharmacogenes affecting tadalafil and finasteride pharmacokinetics, finding fed volunteers had higher drug exposure than fasting individuals, but genetic variation did not significantly impact pharmacokinetics after correcting for multiple comparisons.

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community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Napkin math: are we using 100x more topical finasteride than necessary?

in Finasteride/Dutasteride 4 upvotes 5 months ago

Topical finasteride concentrations are likely much higher than necessary for effective follicular DHT suppression, with current standards being 100-1000 times above the theoretical minimum. Lower concentrations (0.001-0.0025%) might still work locally while minimizing systemic exposure.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 2 years ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Intermittent Finasteride dosing for reduction of side effects?

6 upvotes 7 years ago

Intermittent finasteride dosing, like taking it every third day, may reduce side effects while still lowering DHT levels. Users report side effects such as brain fog and weaker erections, which often subside after stopping the drug.

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