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research New Insight Into the Immunostaining Method Suitable for the Pilosebaceous Complex Unit

June 2015 in “The American journal of dermatopathology/American journal of dermatopathology”

This study demonstrated that a 1-step, peroxidase-labeled conjugated antibody method provides more accurate immunoreactivity patterns in hair follicle substructures compared to the 2-step LSAB method, which may cause false-positive staining in sebaceous glands.

research Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

February 2021 in “Journal of Investigative Dermatology”

This study found that specific junctional proteins are significantly downregulated in balding regions of the scalp in men with androgenetic alopecia, suggesting disrupted cell communication may play a role in hair loss.

research Cutaneous immunopathology of androgenetic alopecia.

10 citations , August 1991 in “PubMed”

This study supports the idea that inflammation may play a role in the development of androgenetic alopecia, as indicated by certain immune deposits and porphyrins found more frequently in bald scalp biopsies compared to controls.

Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgens

research Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgen

56 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

This study demonstrated that steroidal carbamates 7–10 altered mRNA expression related to lipid metabolism in hamster flank organs and inhibited 5α-reductase activity without binding to the progesterone receptor.

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community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

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