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GlossaryPI3K inhibitor

blocks enzyme activity involved in cell growth and survival

A PI3K inhibitor, also known as a phosphoinositide 3-kinase inhibitor, is a type of drug that blocks the activity of the PI3K enzyme. This enzyme is involved in various cellular functions, including growth, proliferation, and survival. By inhibiting PI3K, these drugs can help treat certain cancers and other diseases where PI3K is abnormally active.

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research Activation of Androgen Receptor Sensitizes Breast Carcinomas to NVP-BEZ235's Therapeutic Effect Mediated by PTEN and KLLN Upregulation

23 citations, December 2013 in “Molecular cancer therapeutics”

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

research PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds

9 citations, June 2023 in “Cells”

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

research Androgen Receptor: A Promising Therapeutic Target in Breast Cancer

21 citations, March 2019 in “Critical Reviews in Clinical Laboratory Sciences”

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 119 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.