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research Efficacy, Safety, and Tolerability of Upadacitinib in Adults and Adolescents With Severe Alopecia Areata: Results From the Randomized, Placebo-Controlled, Double-Blind Phase 3 Program (UP-AA)

November 2025 in “SKIN The Journal of Cutaneous Medicine”

In this study, UPA at doses of 15 mg and 30 mg showed higher efficacy than placebo for treating severe alopecia areata in adults and adolescents over 24 weeks, with a safety profile similar to approved uses.

research 60058 Change in patient-reported hair satisfaction during deuruxolitinib treatment of severe alopecia areata: Pooled data from the Phase 3 THRIVE-AA1 and THRIVE-AA2 trials

September 2025 in “Journal of the American Academy of Dermatology”

Deuruxolitinib significantly improves hair satisfaction in severe alopecia areata patients.

research Agreement Between Patient and Physician Assessment of Eyebrow and Eyelash Hair Loss in Two Phase 3 Trials Evaluating Baricitinib in Patients with Severe Alopecia Areata

November 2023 in “Skin”

In this study, a strong positive correlation was found between clinician-reported and patient-reported measures for assessing eyebrow and eyelash hair loss in patients with severe alopecia areata, indicating high agreement during treatment with baricitinib over 52 weeks.

research A phase I safety study of topical calcitriol (BPM 31543) for the prevention of chemotherapy-induced alopecia (CIA).

1 citations , May 2017 in “Journal of Clinical Oncology”

This study found that applying BPM 31543 twice daily was safe, well-tolerated, and showed signs of reducing chemotherapy-induced alopecia in women receiving taxane-based chemotherapy.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

In two phase 3 trials, this study found that oral baricitinib significantly improved hair regrowth compared to placebo in adults with severe alopecia areata after 36 weeks, though longer trials are needed to ascertain its long-term efficacy and safety.

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Community Join

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community Phase 3 Study for PP405 officially posted

43 upvotes 2 weeks ago

PP405 is in a phase 3 trial for hair loss treatment, with the study expected to run until June 2028. Minoxidil and finasteride remain key treatments, with hopes for PP405 to offer a new mechanism of action.

community Phase 3 for PP405 will now start in 2027

in Chat 81 upvotes 1 month ago

Phase 3 for PP405 will start in 2027, disappointing many who expected it this year. Some users are trying treatments like topical minoxidil and topical dutasteride while waiting for new developments.

community Phase 3 of pyrilutamide (kx-836) analysis of the efficacy

in Research/Science 11 upvotes 2 years ago

The conversation discusses the less impressive results of Pyrilutamide (kx-836) in phase 3 compared to phase 2, with a suggestion that a longer study might show more significant results. One user reports personal success with Pyrilutamide, experiencing no further hair loss and gradual regrowth.

community Clascoterone Phase 3 Results and Efficacy

10 upvotes 1 week ago

Clascoterone showed a 2.39x improvement over 12 months, but users are skeptical due to lack of detailed data like actual hair count increase. The conversation questions the efficacy compared to existing treatments like Minoxidil and Finasteride.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 5 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

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Learn

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learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
How long does a hair transplant procedure take? A hair transplant procedure typically takes 4 to 8 hours.
Is shedding normal after a hair transplant? Shedding of transplanted hairs 1–8 weeks after surgery is expected, and regrowth usually starts at 3–5 months. Shock loss of nearby native hair can also happen, so ask your surgeon if shedding persists.

learn Scalp Micropigmentation

How long does Scalp Micropigmentation last, and does it need touch-ups over time? Providers say SMP usually needs a touch-up every 1 to 5 years. It fades but does not fully disappear, and removal needs laser treatment that may be incomplete.

learn Finasteride

Finasteride Results Timeline: How Long It Takes to Work, Shedding Phases, and Expected Outcomes Trial data and community reports both put the first visible changes on finasteride at roughly 3 to 6 months, with the clearest results between 6 and 12 months; some people report an early increase in shedding, but how often this happens has not been measured. The benefit lasts only while the drug is taken, it is prescription-only, and its labels warn of sexual side effects that have continued after stopping in some men, of depression and suicidal thoughts, and of breast and semen changes; some former users also report anxiety and cognitive complaints (see "Is finasteride safe?").

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

learn Baricitinib

JAK inhibitor pill used for severe alopecia areata

learn Fluridil

Topical anti-androgen sold as a cosmetic lotion

learn SCUBE3

Signalling protein made in the hair follicle

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