February 2026 in “Immunity Inflammation and Disease” This study evaluated 386 patients with inborn errors of immunity and found that over half exhibited cutaneous, ocular, or hair manifestations, with bacterial skin infections and eczema being particularly prevalent. These findings may aid early diagnosis, especially in pediatric cases.
27 citations
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July 2017 in “Scientific Reports” This study found that conditional knockout of N-WASP in keratinocytes of mice led to skin barrier defects, increased immune cell infiltration, and hyperproliferation of keratinocytes, indicating its crucial role in skin homeostasis.
9 citations
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December 2021 in “Journal of Cellular and Molecular Medicine” In this study, researchers found that human adipose tissue-derived mesenchymal stromal cells exhibit significant phagocytic ability against various particles and pathogens, which might enhance strategies for addressing specific local and systemic infections due to their regenerative properties.
480 citations
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August 2014 in “Nature Biotechnology” This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.
April 2024 in “Cell death and differentiation” This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.