Human Adipose Tissue-Derived Mesenchymal Stromal Cells And Their Phagocytic Capacity

The study investigated the phagocytic capacity of human adipose tissue-derived mesenchymal stromal cells (HAT-MSCs) isolated from three patients. Using flow cytometry and transmission electron microscopy, the researchers found that HAT-MSCs could phagocytize both biological materials (Escherichia coli, Staphylococcus aureus, and Candida albicans) and non-biological materials (fluorescent latex beads). The percentage of phagocytic cells varied between 33.8% and 56.2%, with a mean of 44.37%. The findings suggested that the high phagocytic capacity of MSCs, combined with their regenerative potential, could enhance treatment strategies for certain infections.