Human Adipose Tissue-Derived Mesenchymal Stromal Cells And Their Phagocytic Capacity

December 2021 in “ Journal of Cellular and Molecular Medicine ”

Víctor J. Costela Ruiz, Lucía Melguizo‐Rodríguez, Rebeca Illescas‐Montes, Enrique García‐Recio, Salvador Arias Santiago, Concepción Ruíz, Elvira De Luna‐Bertos

human adipose tissue-derived mesenchymal stromal cells HAT-MSCs phagocytic capacity flow cytometry transmission electron microscopy immunomodulatory role regenerative medicine immunotherapy

TLDR HAT-MSCs can effectively engulf harmful microbes and particles, aiding infection treatment.

The study investigated the phagocytic capacity of human adipose tissue-derived mesenchymal stromal cells (HAT-MSCs) and found that 33.8% to 56.2% of these cells demonstrated significant phagocytic activity. Using flow cytometry and transmission electron microscopy, the research confirmed that HAT-MSCs could ingest and digest both non-biological materials, like latex beads, and biological targets, such as microorganisms. These findings suggested that HAT-MSCs have an immunomodulatory role and potential clinical relevance in regenerative medicine and immunotherapy, particularly in treating infections and inflammatory processes. Further research was recommended to explore their therapeutic potential.

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