24 citations
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January 2001 in “International Journal of Cancer”
This study from Los Angeles supports the idea that using permanenthair dye may increase bladder cancer risk in US women, especially those with a slow NAT2 acetylation phenotype.
August 2024 in “International Journal of Cosmetic Science”
This study found that acetyl zingerone methyl ether (MAZ) in hairdyes and haircare products may reduce oxidative damage, improve hair condition, and enhance the longevity and quality of dyed hair color.
This study developed and tested a shampoo with semi-permanentdyes designed to gradually cover gray hair, reporting maintained stability and effective gray–black coloration on high-canities hair tresses through eight wash cycles.
November 2016 in “University of the Arts London Research Online (University of the Arts London)”
This study concluded that adding polymeric conditioning actives to shampoos improved color retention in permanently dyed hair, while additional cationic dyes at certain pH levels weakly dyed the hair directly.
12 citations
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December 2017 in “Food and chemical toxicology”
This study found that mixtures used in permanenthairdyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.
A permanenthair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.
Hair regrowth from treatments like minoxidil, RU58841, and finasteride is not permanent; stopping these treatments typically results in hair loss resuming. Beard hair can become permanent with minoxidil use, unlike scalp hair, which requires ongoing treatment to maintain gains.
Hair follicles can experience regrowth with treatments like finasteride, minoxidil, Nizoral, dermarolling, collagen, and biotin, but some may not fully recover. Expectations should be managed as full regrowth to teenage levels may not be possible.
Beard hair grown with minoxidil can become permanent because it is not sensitive to DHT, unlike scalp hair, which requires ongoing minoxidil use even with DHT blockers like finasteride or dutasteride. Dutasteride reduces scalp DHT significantly but not completely, which may explain why scalp hair still needs minoxidil for maintenance.
Shampoos are unlikely to cause permanenthair loss; hair loss is more likely due to male pattern baldness (MPB). The user is advised that losing hair in the shower is normal, and to avoid shampoos with sodium sulfate.
Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.